使用睾酮凝胶与肌肉内制剂相比，用于治疗生长和青春期发育延迟的男性的青春期诱导：初步研究。
Use of testosterone gel compared to intramuscular formulation for puberty induction in males with constitutional delay of growth and puberty: a preliminary study.
机构信息
Endocrinology and Diabetic Unit, University Pediatric Department, Bambino Gesù Children's Hospital, L.go S.Onofrio, 4-00165, Rome, Italy.
出版信息
J Endocrinol Invest. 2018 Feb;41(2):259-263. doi: 10.1007/s40618-017-0726-7. Epub 2017 Jul 10.
PURPOSE
Constitutional delay of growth and puberty (CDGP) treatment include observation or therapy with intramuscular testosterone (IMTT). No data are available about transdermal testosterone gel (TTG). The aim of our study was to analyze the use of TTG in males with CDGP.
METHODS
73 boys with CDGP were divided into three groups: IMTT treated with 50 mg i.m. testosterone; TTG with 10 mg daily 2% testosterone transdermal gel, and no treatment (CNT). All subjects were observed at baseline and after 6 months.
RESULTS
The height velocity after treatment were statistically higher in both IMTT and TTG compared to CNT, while CNT showed higher increase of the testicular volume. No other differences were recorded between IMTT and TTG.
CONCLUSIONS
To our knowledge this is the first study on use of TTG for pubertal activation on CDGP population. Our preliminary data confirm the efficacy of short-term Testosterone gel treatment to induce puberty compared to conventional treatment.
目的
生长和青春期的 constitutional 延迟（CDGP）的治疗包括观察或肌内注射睾酮（IMTT）治疗。目前还没有关于经皮睾酮凝胶（TTG）的数据。我们研究的目的是分析 TTG 在男性 CDGP 中的应用。
方法
73 名 CDGP 男孩分为三组：接受 50mg 肌肉注射睾酮的 IMTT；每天接受 10mg 2%睾酮经皮凝胶治疗的 TTG 和无治疗（CNT）。所有受试者均在基线和 6 个月后进行观察。
结果
与 CNT 相比，IMTT 和 TTG 治疗后的身高增速均具有统计学意义，而 CNT 显示睾丸体积增加更高。IMTT 和 TTG 之间没有记录到其他差异。
结论
据我们所知，这是第一项关于 TTG 在 CDGP 人群中用于青春期激活的研究。我们的初步数据证实了短期睾酮凝胶治疗与传统治疗相比诱导青春期的疗效。
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