Smaś-Suska Monika, Dłużniewska Natalia, Weryński Piotr, Pająk Jacek, Płazak Wojciech, Olszowska Maria, Podolec Piotr, Tomkiewicz-Pająk Lidia
Jagiellonian University Medical College Institute of Cardiology Departament of Cardiac and Vascular Diseases.
Cardiol J. 2018;25(1):72-80. doi: 10.5603/CJ.a2017.0078. Epub 2017 Jul 11.
Despite the low early mortality of Fontan procedures, Fontan patients are prone to vari-ous cardiac and extra-cardiac complications in the long term. This may influence patient perception of their health and outcome. The aim of the study was to assess the relationship of multi-organ compli-cations and physical efficiency with self-reported health-related quality of life (QOL) in adult Fontan patients.
Quality of life was assessed with the Short Form-36 questionnaire. Laboratory tests were done together with echocardiography, plethysmography, and cardiopulmonary exercise test.
The QOL was poorer in patients than in control subjects. The physical characteristics of patients correlated with dynamic ventilatory parameters, heart rate at the peak of exercise, alanine aminotransferase and albumin level.
Liver impairment and chronotropic incompetence during exercise are associated with poor QOL in patients after Fontan procedure. In these patient, hepatic, pulmonary and cardiac functions should be carefully monitored. (Cardiol J 2018; 25, 1: 72-80).
尽管Fontan手术早期死亡率较低，但从长期来看，Fontan手术患者容易出现各种心脏和心外并发症。这可能会影响患者对自身健康和预后的认知。本研究的目的是评估成年Fontan手术患者多器官并发症和身体机能与自我报告的健康相关生活质量（QOL）之间的关系。
采用简短健康调查问卷（Short Form-36 questionnaire）评估生活质量。同时进行实验室检查、超声心动图检查、体积描记法检查和心肺运动试验。
患者的生活质量低于对照组。患者的身体特征与动态通气参数、运动峰值时的心率、丙氨酸转氨酶和白蛋白水平相关。
Fontan手术后患者运动时肝功能损害和变时性功能不全与生活质量差有关。对于这些患者，应仔细监测肝脏、肺部和心脏功能。（《心脏病学杂志》2018年；25卷，第1期：72-80页）
