复发性外阴阴道假丝酵母菌病患者分离株形成的生物膜具有异质性且对氟康唑不敏感。
Biofilms Formed by Isolates from Recurrent Vulvovaginal Candidiasis Patients Are Heterogeneous and Insensitive to Fluconazole.
机构信息
Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Institute of Healthcare Policy and Practice, School of Health, Nursing and Midwifery, University of West of Scotland, Paisley, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2017 Aug 24;61(9). doi: 10.1128/AAC.01065-17. Print 2017 Sep.
Abstract
Vulvovaginal candidiasis (VVC) is a global health problem affecting ∼75% of women at least once in their lifetime. Here we examined the epidemiology of VVC in a patient cohort to identify the causative organisms associated with VVC. Biofilm-forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of species with heterogeneous biofilm-forming capacity, which is associated with altered antifungal drug sensitivity.
摘要
外阴阴道念珠菌病（VVC）是一个全球性的健康问题，影响到至少 75%的女性一生中至少一次。在这里，我们检查了一个患者队列中的 VVC 流行病学，以确定与 VVC 相关的致病生物体。还评估了生物膜形成能力和抗真菌药物敏感性谱。我们报告了 种的流行率变化，具有异质的生物膜形成能力，这与抗真菌药物敏感性的改变有关。
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