Garza-Mayers Anna Cristina, Kroshinsky Daniela
J Drugs Dermatol. 2017 Jul 1;16(7):705-706.
BACKGROUND: Treatment of vitiligo is aimed at repigmentation and often consists of multiple modalities, none of which are universally or rapidly successful. Extensive cases are most often treated with ultraviolet light therapy, which can be both costly and time-consuming. Though vitiligo is an autoimmune disease, there is no current data to support systemic immunosuppressive monotherapy.
CASE SUMMARY: Here we present a case series of 3 patients with vitiligo treated for 11-16 months with low-dose methotrexate (12.5-25 mg per week) with folic acid supplementation with clinically significant skin repigmentation, with response within 6 months in one case. There were no severe adverse effects reported.
CONCLUSION: These cases demonstrate an unexplored effective and steroid-sparing therapeutic alternative in patients with vitiligo for whom topical therapy has failed and phototherapy is cost-prohibitive or ineffective.
J Drugs Dermatol. 2017;16(7):705-706.
.白癜风的治疗旨在实现色素再生，通常包括多种治疗方式，但没有一种能普遍或迅速取得成功。广泛型病例最常采用紫外线光疗，这既昂贵又耗时。尽管白癜风是一种自身免疫性疾病，但目前尚无数据支持全身性免疫抑制单一疗法。
在此，我们报告一组3例白癜风患者的病例系列，这些患者接受低剂量甲氨蝶呤（每周12.5 - 25毫克）加叶酸补充剂治疗11 - 16个月，出现了具有临床意义的皮肤色素再生，其中1例在6个月内出现反应。未报告严重不良反应。
这些病例证明，对于局部治疗失败且光疗费用过高或无效的白癜风患者，存在一种未被探索的有效且能减少类固醇使用的治疗选择。
《皮肤药物学杂志》。2017年；16(7):705 - 706。
