Ogasawara T, Hoensch H, Ohnhaus E E
Arch Toxicol Suppl. 1985;8:110-3. doi: 10.1007/978-3-642-69928-3_13.
Glutathione (GSH) concentration of whole mucosa was 2.96 +/- 0.26 (mean +/- SEM) mumol/g wet weight in all segments: however the tip cell layer contained significantly less GSH than the lower mucosal cells. GSH S-transferase (GSH-T) activities displayed a striking gradient with highest values in the duodenum and lowest in the terminal ileum. gamma-glutamyl transpeptidase (GGT) activities were also highest in the proximal segment but lowest in the fifth segment among eight divided segments. Along the villus/crypt axis GGT and to a lesser degree GSH-T were also polarized with highest activities in the villus tip cell region. GSH peroxidase (GSH-Px) and glutathione reductase (GSSG-R) had an even distribution along the intestinal tube and among the mucosal cell populations. This distinct pattern of distribution suggests a functional adaptation of GSH and its related enzymes; GSH-T might be important for detoxification of exogenous luminal compounds which enter the body in the upper intestinal segments while GSH-Px might be responsible for peroxidation of endogenously produced compounds.
全层黏膜的谷胱甘肽（GSH）浓度在所有节段均为2.96±0.26（平均值±标准误）μmol/g湿重；然而，顶端细胞层所含的GSH明显少于下层黏膜细胞。谷胱甘肽S-转移酶（GSH-T）活性呈现出显著的梯度变化，十二指肠中的活性最高，回肠末端最低。γ-谷氨酰转肽酶（GGT）活性在近端节段也最高，但在八个分段中的第五节段最低。沿绒毛/隐窝轴，GGT以及程度稍低的GSH-T也呈极化分布，在绒毛顶端细胞区域活性最高。谷胱甘肽过氧化物酶（GSH-Px）和谷胱甘肽还原酶（GSSG-R）在肠道及黏膜细胞群体中分布均匀。这种独特的分布模式表明GSH及其相关酶具有功能适应性；GSH-T可能对外源性肠腔化合物的解毒很重要，这些化合物在上段肠道进入体内，而GSH-Px可能负责内源性产生化合物的过氧化反应。
