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T 细胞受体的 V-J 组合可预测终末期肾病患者对红细胞生成素的反应。

V-J combinations of T-cell receptor predict responses to erythropoietin in end-stage renal disease patients.

机构信息

Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, No. 250, Wuxing St, Xinyi District, Taipei City, 11031, Taiwan.

Master's Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, No. 250, Wuxing St, Xinyi District, Taipei City, 11031, Taiwan.

出版信息

J Biomed Sci. 2017 Jul 11;24(1):43. doi: 10.1186/s12929-017-0349-5.

DOI:10.1186/s12929-017-0349-5
PMID:28697735
原文链接:
https://pmc.ncbi.nlm.nih.gov/articles/PMC5504791/
Abstract

BACKGROUND

Anemia is common among end-stage renal disease (ESRD) patients who undergone hemodialysis. The total reduction of red blood cell (RBC) count is associated with poor prognosis in these patients. Although erythropoietin (EPO) has been used as an effective treatment for ESRD patients with anemia, a large number of patients still present poor responses to EPO treatment.

METHODS

We measured T-cell receptor sequencing profiles, including length of complementarity-deteremining region 3 (CDR3), intra- and inter-group (EPO resistant vs. responsive) clonotype diversity, V(D)J usage profiles and V-J combinations from ESRD patients and to investigate the correlation between these features and EPO treatment efficacy.

RESULTS

Our results revealed statistical significance in the top 3 ~ 15 most abundant joint distributions of Vβ/Jβ among the two groups, suggesting the importance of V or J gene utilization in the EPO response of ESRD patients.

CONCLUSIONS

In summary, we provided evidence addressing the potential correlation between the immune repertoire and EPO response in ESRD patients.

TRIAL REGISTRATION

TMU-JIRB 201309026. Registered 16 October 2013.

摘要

背景

贫血在接受血液透析的终末期肾病（ESRD）患者中很常见。这些患者的红细胞（RBC）计数总减少与预后不良有关。尽管促红细胞生成素（EPO）已被用作治疗 ESRD 贫血患者的有效方法，但仍有大量患者对 EPO 治疗反应不佳。

方法

我们测量了 T 细胞受体测序谱，包括互补决定区 3（CDR3）的长度、内群和外群（EPO 抵抗与反应）克隆型多样性、V(D)J 使用谱和 ESRD 患者的 V-J 组合，以研究这些特征与 EPO 治疗效果之间的相关性。

结果

我们的结果表明，在两组中，前 3 个~15 个最丰富的 Vβ/Jβ联合分布存在统计学意义，这表明 V 或 J 基因利用在 ESRD 患者对 EPO 的反应中很重要。

结论

综上所述，我们提供了证据，证明了免疫受体库与 ESRD 患者对 EPO 反应之间存在潜在的相关性。

试验注册

TMU-JIRB 201309026. 2013 年 10 月 16 日注册。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d079/5504791/98e262ade914/12929_2017_349_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d079/5504791/88f22184c59b/12929_2017_349_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d079/5504791/e3afe822b491/12929_2017_349_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d079/5504791/bfd2102029a8/12929_2017_349_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d079/5504791/2e8a209bb758/12929_2017_349_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d079/5504791/2b80eb25e367/12929_2017_349_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d079/5504791/98e262ade914/12929_2017_349_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d079/5504791/88f22184c59b/12929_2017_349_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d079/5504791/e3afe822b491/12929_2017_349_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d079/5504791/bfd2102029a8/12929_2017_349_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d079/5504791/2e8a209bb758/12929_2017_349_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d079/5504791/2b80eb25e367/12929_2017_349_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d079/5504791/98e262ade914/12929_2017_349_Fig6_HTML.jpg

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