Acevedo-Negrete Ana Paula, Porchia Leonardo M, Gonzalez-Mejia M Elba, Torres-Rasgado Enrique, Solis-Cano Dania G, Ruiz-Vivanco Guadalupe, Pérez-Fuentes Ricardo
Laboratorio de Investigación en Fisiopatología de Enfermedades Crónicas, Centro de Investigación Biomédica de Oriente, IMSS, Carretera Federal Atlixco-Metepec Km 4.5, C.P. 42730 Atlixco, Pue, Mexico.
Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Calle 13 Sur 2901 Colonia Volcanes, C.P. 72000, Puebla, Pue, Mexico.
Diabetes Metab Syndr. 2017 Dec;11 Suppl 2:S895-S900. doi: 10.1016/j.dsx.2017.07.012. Epub 2017 Jul 3.
Hyperinsulinemia and insulin resistance are both associated with the development of Type 2 Diabetes and other pathologies; however, the influence of parental history of Type 2 diabetes (PH-T2D) has yet to be investigated. Therefore, this study was conducted to determine the effect of PH-T2D has on the risk of developing hyperinsulinemia and IR.
1092 subjects (703 non-pregnant females and 389 males) were enrolled for a cross-sectional study. Clinical and biochemical parameters were collected. Subjects were allocated according to their PH-T2D: no parents, one parent, or both parents. Insulin resistance was calculated using the HOMA1 equation (HOMA1-IR). Logistic regression was used to determine the association (odds ratio) between PH-T2D and hyperinsulinemia or insulin resistance.
Increasing degrees of PH-T2D were associated with significant increases in fasting plasma glucose, insulin, and HOMA1-IR (p <0.05). Subjects having one or both parents were associated with an increase risk of developing hyperinsulinemia (odds ratio=1.53, 95%CI: 1.12-2.09, and odds ratio=1.92, 95%CI: 1.21-3.06, respectively) and insulin resistance (odds ratio=1.47, 95%CI: 1.08-2.00 and odds ratio=1.77, 95%CI: 1.09-2.87, respectively), when adjusting for age, sex, BMI, fasting plasma glucose, and triglycerides.
The presences of PH-T2D significantly increased the risk of developing hyperinsulinemia and insulin resistance.
高胰岛素血症和胰岛素抵抗均与2型糖尿病及其他病症的发生有关；然而，2型糖尿病家族史（PH-T2D）的影响尚未得到研究。因此，本研究旨在确定PH-T2D对发生高胰岛素血症和胰岛素抵抗风险的影响。
1092名受试者（703名未怀孕女性和389名男性）参与了一项横断面研究。收集了临床和生化参数。受试者根据其PH-T2D情况进行分组：无父母患2型糖尿病、父母一方患2型糖尿病或父母双方患2型糖尿病。使用HOMA1方程（HOMA1-IR）计算胰岛素抵抗。采用逻辑回归分析来确定PH-T2D与高胰岛素血症或胰岛素抵抗之间的关联（优势比）。
PH-T2D程度的增加与空腹血糖、胰岛素和HOMA1-IR的显著升高相关（p<0.05）。在调整年龄、性别、体重指数、空腹血糖和甘油三酯后，父母一方或双方患2型糖尿病的受试者发生高胰岛素血症（优势比分别为1.53，95%置信区间：1.12-2.09和优势比为1.92，95%置信区间：1.21-3.06）和胰岛素抵抗（优势比分别为1.47，95%置信区间：1.08-2.00和优势比为1.77，95%置信区间：1.09-2.87）的风险增加。
PH-T2D的存在显著增加了发生高胰岛素血症和胰岛素抵抗的风险。
