β-环糊精-银/聚乙烯醇水凝胶基底的快速表面增强拉曼散射（SERS）检测盐酸西布曲明在药用胶囊中的应用。
Rapid Surface Enhanced Raman Scattering (SERS) Detection of Sibutramine Hydrochloride in Pharmaceutical Capsules with a β-Cyclodextrin- Ag/Polyvivnyl Alcohol Hydrogel Substrate.
机构信息
School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Key Laboratory of Catalysis and Materials Science of the State Ethnic Affairs Commission and Ministry of Education, College of Resources and Environmental Science, South Central University for Nationalities, Wuhan 430074, China.
出版信息
Sensors (Basel). 2017 Jul 10;17(7):1601. doi: 10.3390/s17071601.
Sibutramine hydrochloride (SH) is a banned weight-loss drug, but its illegal addition to health products is still rampant. This suggests a very urgent need for a fast and precise detection method for SH. Surface Enhanced Raman Scattering (SERS) is a promising candidate for this purpose, but the weak affinity between SH and bare metal limits its direct SERS detection. In the present work, β-cyclodextrin was capped in situ onto the surface of Ag nanoparticles to function as a scaffold to capture SH. The obtained Ag nanoparticles were encapsulated into polyvinyl alcohol (PVA) to fabricate a SERS active hydrogel with excellent reproducibility. A facile SERS strategy based on such substrate was proposed for trace SH quantification with a linear range of 7.0-150.0 µg·mL, and a detection limit low to 3.0 µg·mL. It was applied to analyze seven types of commercial slimming capsules with satisfactory results, showing good prospect for real applications.
盐酸西布曲明（SH）是一种被禁用的减肥药，但它仍被非法添加到保健品中。这表明非常需要一种快速准确的 SH 检测方法。表面增强拉曼散射（SERS）是一种很有前途的候选方法，但 SH 与裸金属之间的弱亲和力限制了其直接 SERS 检测。在本工作中，β-环糊精被原位包覆在银纳米粒子表面，作为捕获 SH 的支架。所得的银纳米粒子被包封在聚乙烯醇（PVA）中，以制备具有出色重现性的 SERS 活性水凝胶。基于这种基底提出了一种简单的 SERS 策略，用于痕量 SH 的定量分析，线性范围为 7.0-150.0 µg·mL，检测限低至 3.0 µg·mL。它被应用于分析七种类型的商业减肥胶囊，结果令人满意，显示出实际应用的良好前景。
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