Institute of Chemistry, Saratov State University, Astrakhanskaya 83, 410012, Saratov, Russia.
Leibniz Institute of Photonic Technology, Member of the Leibniz Research Alliance, "Leibniz Health Technologies", Albert-Einstein-Straße 9, 07745, Jena, Germany.
Anal Bioanal Chem. 2022 Jan;414(2):923-942. doi: 10.1007/s00216-021-03704-x. Epub 2021 Oct 11.
Numerous approaches have been proposed to overcome the intrinsically low selectivity of surface-enhanced Raman spectroscopy (SERS), and the modification of SERS substrates with diverse recognition molecules is one of such approaches. In contrast to the use of antibodies, aptamers, and molecularly imprinted polymers, application of cyclodextrins (CDs) is still developing with less than 100 papers since 1993. Therefore, the main goal of this review is the critical analysis of all available papers on the use of CDs in SERS analysis, including physicochemical studies of CD complexation and the effect of CD presence on the Raman enhancement. The results of the review reveal that there is controversial information about CD efficiency and further experimental investigations have to be done in order to estimate the real potential of CDs in SERS-based analysis.
已经提出了许多方法来克服表面增强拉曼光谱（SERS）固有的低选择性，其中一种方法是用各种识别分子修饰 SERS 基底。与使用抗体、适体和分子印迹聚合物相比，自 1993 年以来，环糊精（CDs）的应用仍在发展，相关论文不足 100 篇。因此，本综述的主要目标是对所有关于 CD 在 SERS 分析中应用的可用论文进行批判性分析，包括 CD 配合物的物理化学研究以及 CD 存在对拉曼增强的影响。综述结果表明，关于 CD 效率的信息存在争议，需要进一步进行实验研究，以评估 CDs 在基于 SERS 的分析中的实际潜力。
