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从一名患有链球菌中毒性休克综合征的日本患者身上分离出的M3-b菌株3的全基因组序列及比较基因组学

Complete Genome Sequence and Comparative Genomics of a 3 Strain M3-b isolated from a Japanese Patient with Streptococcal Toxic Shock Syndrome.

作者信息

Ogura Kohei, Watanabe Shinya, Kirikae Teruo, Miyoshi-Akiyama Tohru

机构信息

Pathogenic Microbe Laboratory.

Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.

出版信息

J Genomics. 2017 Jul 1;5:71-74. doi: 10.7150/jgen.20915. eCollection 2017.

DOI:10.7150/jgen.20915
PMID:28698738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5504827/
Abstract

Epidemiologic typing of (GAS) is frequently based on the genotype of the gene, which encodes M/Emm protein. In this study, the complete genome sequence of GAS strain M3-b, isolated from a patient with streptococcal toxic shock syndrome (STSS), was determined. This strain exhibited 99% identity with other complete genome sequences of strains MGAS315, SSI-1, and STAB902. The complete genomes of five additional strains isolated from Japanese patients with and without STSS were also sequences. Maximum-likelihood phylogenetic analysis showed that strains M3-b, M3-e, and SSI-1, all which were isolated from STSS patients, were relatively close.

摘要

A群链球菌（GAS）的流行病学分型通常基于编码M/Emm蛋白的emm基因的基因型。在本研究中，测定了从一名链球菌中毒性休克综合征（STSS）患者分离出的GAS菌株M3-b的全基因组序列。该菌株与其他A群链球菌菌株MGAS315、SSI-1和STAB902的全基因组序列具有99%的同一性。还对从患有和未患有STSS的日本患者中分离出的另外五株菌株的全基因组进行了测序。最大似然系统发育分析表明，均从STSS患者中分离出的菌株M3-b、M3-e和SSI-1相对接近。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe32/5504827/0e5567b7ed4b/jgenv05p0071g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe32/5504827/aa5eaa4f4a2c/jgenv05p0071g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe32/5504827/0e5567b7ed4b/jgenv05p0071g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe32/5504827/aa5eaa4f4a2c/jgenv05p0071g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe32/5504827/0e5567b7ed4b/jgenv05p0071g002.jpg

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