Ghosh Kinjalka, Muddeshwar M G, Lokhande Manoj, Ghosh Kanjaksha
Department of Biochemistry, Indira Gandhi Government Medical College (IGGMC), Nagpur, Maharashtra-440018. India.
Surat Raktadan Kendra and Research Centre, Surat 395002, Gujrat. India.
Mediterr J Hematol Infect Dis. 2017 Jun 16;9(1):e2017041. doi: 10.4084/MJHID.2017.041. eCollection 2017.
We evaluated albumin cobalt binding (ACB) assay also known as Ischaemia Modified Albumin (IMA) assay as a prognostic marker for severe malaria in a medical college setting.
Consecutive adult patients admitted with both vivax and falciparum malaria were evaluated with ACB assay at the time of admission. Detailed work up and individual patient directed management were instituted in addition to immediate artemisin based antimalarial therapy.
100 consecutive patients (50 with vivax and 50 with falciparum malaria) were evaluated. The reference range for ACB assay was established using 50 adult healthy (25 male and 25 female) individuals. 16 out of 50 p. Falciparum-Infected developed complicated malaria. None of the P Vivax patients developed complicated malaria. All malaria infected patients had high ACB levels (P<0.0001). There was a stepwise increase in ACB levels from healthy volunteers to different categories of malaria (P<0.0001) without any overlap.
ACB has the potential to be used as a robust simple and inexpensive prognostic marker for organ dysfunction in severe malaria even if an evaluation at multiple sites with a bigger number of patients should be initiated for final recommendation.
我们评估了白蛋白钴结合（ACB）检测法，即缺血修饰白蛋白（IMA）检测法，作为医学院环境中重症疟疾预后标志物的情况。
对因间日疟和恶性疟连续入院的成年患者在入院时采用ACB检测法进行评估。除了立即给予以青蒿素为基础的抗疟治疗外，还进行了详细检查和针对个体患者的管理。
对100例连续患者（50例间日疟患者和50例恶性疟患者）进行了评估。使用50名成年健康个体（25名男性和25名女性）建立了ACB检测法的参考范围。50例恶性疟感染患者中有16例发展为复杂性疟疾。间日疟患者均未发展为复杂性疟疾。所有疟疾感染患者的ACB水平均较高（P<0.0001）。从健康志愿者到不同类型的疟疾患者，ACB水平呈逐步升高趋势（P<0.0001），且无任何重叠。
ACB有潜力作为重症疟疾器官功能障碍的一种强大、简单且廉价的预后标志物，尽管为了最终推荐，应在更多地点对更多患者进行评估。
