Galiniak Sabina, Mołoń Mateusz, Biesiadecki Marek, Bożek Agnieszka, Rachel Marta
Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow University, Warzywna 1a, 35-310 Rzeszow, Poland.
Department of Biology, Institute of Biology and Biotechnology, Rzeszow University, Zelwerowicza 4, 35-601 Rzeszow, Poland.
Antioxidants (Basel). 2022 Aug 16;11(8):1590. doi: 10.3390/antiox11081590.
Atopic dermatitis (AD) and chronic urticaria (CU) are common skin diseases with an increasing prevalence and pathogenesis that are not fully understood. Emerging evidence suggests that oxidative stress plays a role in AD and CU. The aim of the single-center cross-sectional study was to compare markers of oxidative stress in 21 patients with AD, and 19 CU patients. The products of protein oxidation, total antioxidant capacity (TAC), and markers of lipid peroxidation were estimated in the serum. AD patients had a higher level of advanced protein oxidation products and a lower level of thiol groups than healthy participants. However, CU patients had statistically higher levels of AOPP and 3-nitrotyrosine than healthy subjects. The level of thiol groups and serum TAC decreased significantly in patients with CU. There was no difference in serum concentration of lipid peroxidation products, Amadori products, ratio of reduced to oxidized glutathione, and ability of albumin to binding cobalt between AD or CU patients compared to healthy subjects. We found a moderate positive significant correlation between AOPP and age in patients with AD. In patients with CU, TAC was negatively correlated with age. These results may shed light on the etiopathogenesis of AD or CU, and confirm an oxidative burden in these patients. Furthermore, our study could be useful in developing new therapeutic methods that include using antioxidants in dermatological diseases.
特应性皮炎（AD）和慢性荨麻疹（CU）是常见的皮肤病，其患病率不断上升，发病机制尚未完全明确。新出现的证据表明氧化应激在AD和CU中起作用。这项单中心横断面研究的目的是比较21例AD患者和19例CU患者的氧化应激标志物。对血清中的蛋白质氧化产物、总抗氧化能力（TAC）和脂质过氧化标志物进行了评估。与健康参与者相比，AD患者的晚期蛋白质氧化产物水平较高，巯基水平较低。然而，CU患者的AOPP和3-硝基酪氨酸水平在统计学上高于健康受试者。CU患者的巯基水平和血清TAC显著降低。与健康受试者相比，AD或CU患者的脂质过氧化产物、Amadori产物、还原型谷胱甘肽与氧化型谷胱甘肽的比率以及白蛋白结合钴的能力的血清浓度没有差异。我们发现AD患者中AOPP与年龄之间存在中度正相关。在CU患者中，TAC与年龄呈负相关。这些结果可能有助于阐明AD或CU的病因发病机制，并证实这些患者存在氧化负担。此外，我们的研究可能有助于开发新的治疗方法，包括在皮肤病中使用抗氧化剂。
