Kamal Eldin Tarek, Tosone Grazia, Capuano Alfredo, Orlando Raffaele
Section of Viral Diseases, Department of Clinical Medicine, University Hospital 'Federico II' of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy.
Section of Haemodialysis Techniques and Peritoneal Dialysis, Department of Specialty Surgery and Nephrology, University Hospital 'Federico II' of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy.
Drug Saf Case Rep. 2017 Dec;4(1):10. doi: 10.1007/s40800-017-0052-1.
We present the case of a 58-year-old woman who developed hypokalaemia and metabolic alkalosis 2 weeks after therapy with colistimethate sodium for the treatment of chronic lower limb ulcer infection by extensively drug-resistant (XDR) Pseudomonas aeruginosa. The metabolic changes observed resembled Bartter syndrome, a group of congenital disorders affecting the distal segments of the renal tubules. The metabolic abnormalities reversed spontaneously 6 days after drug discontinuation. Acquired forms of Bartter syndrome have been reported during courses of antibiotic therapy; however, to our knowledge, this is the first documented case associated with colistimethate therapy in an adult.
我们报告一例58岁女性病例，该患者在使用多粘菌素甲磺酸钠治疗广泛耐药性（XDR）铜绿假单胞菌引起的慢性下肢溃疡感染2周后出现低钾血症和代谢性碱中毒。观察到的代谢变化类似于巴特综合征，这是一组影响肾小管远端节段的先天性疾病。停药6天后，代谢异常自发逆转。抗生素治疗过程中曾报告过获得性巴特综合征；然而，据我们所知，这是第一例记录在案的与多粘菌素甲磺酸钠治疗相关的成人病例。
