Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.
Investigative Science, Imperial College London, London, UK.
Curr Obes Rep. 2017 Sep;6(3):246-252. doi: 10.1007/s13679-017-0270-y.
Bariatric surgery is currently the most effective treatment for obesity. Roux-en-Y gastric bypass (RYGB) is the most commonly performed bariatric procedure and results in long-term weight loss. Alterations in food preference and choices may contribute to the long-term benefits of RYGB. This manuscript reviews the available literature documenting changes in food preference in both humans and experimental animals after RYGB and discusses the current theory on the underlying mechanisms involved.
Obesity is associated with an increased preference for sweet and high-fat foods, and the most consistent evidence has been the shift away from these calorie-dense foods in both animal and human studies after RYGB. Self-reporting is the most common method used to record food preferences in humans, while more direct approaches have been used in animal work. This methodological heterogeneity may give rise to inconsistent findings. Future studies in humans should focus on direct measures to permit corroboration of mechanistic insights gained from animal studies.
减重手术是目前治疗肥胖最有效的方法。Roux-en-Y 胃旁路术（RYGB）是最常进行的减重手术，可长期减轻体重。食物偏好和选择的改变可能有助于 RYGB 的长期获益。本文综述了现有文献，记录了 RYGB 后人类和实验动物食物偏好的变化，并讨论了目前关于相关潜在机制的理论。
肥胖与对甜食和高脂肪食物的偏好增加有关，最一致的证据是 RYGB 后动物和人类研究中对这些高热量食物的摄入量减少。在人类中，自我报告是最常用的记录食物偏好的方法，而在动物研究中则使用了更直接的方法。这种方法学的异质性可能导致研究结果不一致。未来的人类研究应侧重于直接测量，以证实从动物研究中获得的机制见解。
