The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Hunan key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Curr Pharm Des. 2017 Nov 16;23(29):4410-4421. doi: 10.2174/1381612823666170710144759.
CD147 is a membrane protein belonging to immunoglobulin superfamily and expressed in the cell membrane, which is also named with an extracellular matrix metalloproteinase inducer (EMMPRIN) because this molecule induces adjacent fibroblasts or tumor cells to produce MMPs, facilitating tumor cells migration and invasion. Accumulating evidences have shown that CD147 is over-expressed in various tumors, including melanoma, liver cancer, and lung cancer, and orchestrates tumor cell proliferation, apoptosis, invasion and metastasis, multidrug resistance and glycolysis through critical molecules such as MMPs, MCTs, Caveolin-1, and VEGF. In this review, we focus on understanding the characteristics of CD147 in various biological functions, including physiological and pathological processes. Recent novel studies have shown that CD147 is not only a potential diagnostic marker but also a therapeutic target for chemotherapy or the diagnosis of cancer.
CD147 是一种免疫球蛋白超家族的膜蛋白，表达于细胞膜上，因其能诱导相邻成纤维细胞或肿瘤细胞产生 MMPs 而被称为细胞外基质金属蛋白酶诱导因子（EMMPRIN），有利于肿瘤细胞的迁移和侵袭。越来越多的证据表明，CD147 在多种肿瘤中过度表达，包括黑色素瘤、肝癌和肺癌，并通过 MMPs、MCTs、Caveolin-1 和 VEGF 等关键分子调控肿瘤细胞的增殖、凋亡、侵袭和转移、多药耐药和糖酵解。在这篇综述中，我们重点探讨了 CD147 在包括生理和病理过程在内的各种生物学功能中的特征。最近的新研究表明，CD147 不仅是一种潜在的诊断标志物，也是化疗或癌症诊断的治疗靶点。
