a GSK Vaccines , Rockville , MD , USA.
Expert Rev Vaccines. 2017 Sep;16(9):871-881. doi: 10.1080/14760584.2017.1355245. Epub 2017 Jul 28.
The present review summarizes the growing body of work defining the mechanisms of action of this exciting new vaccine technology that should allow rational approaches in the design of next generation mRNA vaccines. Areas covered: Bio-distribution of mRNA, localization of antigen production, role of the innate immunity, priming of the adaptive immune response, route of administration and effects of mRNA delivery systems. Expert commentary: In the last few years, the development of RNA vaccines had a fast growth, the rising number of proof will enable rational approaches to improving the effectiveness and safety of this modern class of medicine.
本篇综述总结了越来越多的研究成果，阐述了这一令人兴奋的新型疫苗技术的作用机制，这将为下一代 mRNA 疫苗的设计提供合理的方法。涵盖领域：mRNA 的生物分布、抗原产生的定位、先天免疫的作用、适应性免疫反应的引发、给药途径以及 mRNA 传递系统的影响。专家评论：在过去几年中，RNA 疫苗的发展迅速增长，越来越多的证据将使人们能够合理地提高这种现代药物类别的有效性和安全性。
