Batisani Kesaobaka
School of Medicine and Health Sciences, University of Lusaka, Lusaka, Zambia.
Trop Dis Travel Med Vaccines. 2025 May 15;11(1):12. doi: 10.1186/s40794-025-00246-3.
The emergence of messenger RNA (mRNA) vaccines has marked a seminal shift in the field of immunization, heralding an era characterized by unprecedented speed and efficacy in the face of infectious diseases. The global crisis caused by the COVID-19 pandemic catalyzed the rapid development and deployment of two leading mRNA vaccines, Comirnaty and SpikeVax, showcasing not only the technological promise of mRNA, but also its transformative potential in public health strategies. This study seeks to provide an in-depth exploration of the foundational elements of mRNA vaccine technology, elucidate its unique advantages over traditional vaccine platforms, analyze the existing challenges that public health officials face, and envision future applications that extend far beyond current expectations. Through this exploration, we advocate for the integration of mRNA technology into existing public health frameworks to enhance global health security and adaptability in the face of emerging infectious threats.
信使核糖核酸（mRNA）疫苗的出现标志着免疫领域的一次重大转变，预示着一个在应对传染病方面具有前所未有的速度和效力的时代。由新冠疫情引发的全球危机促使两种领先的mRNA疫苗——复必泰（Comirnaty）和斯派维克斯（SpikeVax）迅速研发和部署，这不仅展示了mRNA的技术前景，也展现了其在公共卫生战略中的变革潜力。本研究旨在深入探讨mRNA疫苗技术的基础要素，阐明其相较于传统疫苗平台的独特优势，分析公共卫生官员面临的现有挑战，并展望远远超出当前预期的未来应用。通过这一探索，我们倡导将mRNA技术融入现有的公共卫生框架，以增强全球卫生安全以及面对新出现的传染病威胁时的适应能力。
