Thomas Zachary M, Staudinger Gabriel J, Hooper Sarah E, Williams Jeffrey F, Robins Lori I
Physical Sciences Division, University of Washington Bothell, Bothell, WA 98011, USA.
Microbiology & Infection Research Group, Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff CF5 2YB, UK.
Int J Mol Sci. 2025 Sep 5;26(17):8677. doi: 10.3390/ijms26178677.
The stability of a formulation of 1% N-chlorotaurine (NCT) in a smectite clay as a gel was characterized using a range of physicochemical parameters, and its antimicrobial efficacy was determined against and . The stability of the NCT gel was determined by UV-visible spectroscopy. The efficacy against and was tested in single- and dual-species biofilms using a dynamic in vitro chronic wound infection model and only showed efficacy against . The gel proved stable over time at room temperature and at 4 °C with half-life values of ~161 days and 4 years, respectively. The compatibility of NCT with the preferred pH of the clay gel makes this formulation a candidate for durable topical application to chronic wounds.
使用一系列物理化学参数对1%氯牛磺酸（NCT）在蒙脱石粘土凝胶制剂中的稳定性进行了表征，并测定了其对[具体菌种1]和[具体菌种2]的抗菌效果。通过紫外可见光谱法测定了NCT凝胶的稳定性。使用动态体外慢性伤口感染模型在单菌种和双菌种生物膜中测试了对[具体菌种1]和[具体菌种2]的抗菌效果，结果仅显示对[具体菌种1]有效。该凝胶在室温下和4℃时随时间推移均表现出稳定性，半衰期分别约为161天和4年。NCT与粘土凝胶的适宜pH值的兼容性使得该制剂成为用于慢性伤口持久局部应用的候选产品。
