Tan H E, Lan N S R, Knuiman M W, Divitini M L, Swanepoel D W, Hunter M, Brennan-Jones C G, Hung J, Eikelboom R H, Santa Maria P L
Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Ear Science Institute Australia, Subiaco, WA, Australia.
Clin Otolaryngol. 2018 Feb;43(1):172-181. doi: 10.1111/coa.12936. Epub 2017 Aug 9.
To investigate the relationship between hearing loss and cardiovascular disease risk factors.
Cross-sectional study.
Participants were recruited between May 2010 and December 2015 and answered a health and risk factor questionnaire. Physical and biochemical assessments were performed.
A community-based population.
A total of 5107 participants born within the years 1946-1964 enrolled in the Busselton Healthy Ageing Study.
Hearing was assessed behaviourally through the best ear pure-tone average (500, 1000, 2000, 4000 Hz), low-frequency average (250, 500, 1000 Hz) and high-frequency average (4000, 8000 Hz). Self-reported hearing loss, tinnitus and hyperacusis were assessed via questionnaire. Cardiovascular risk factors were assessed via a patient-completed questionnaire and objective measurements including blood pressure, body mass index, waist circumference, lipid profile and glycated haemoglobin.
Of the participants, 54% were female, with the mean age of 58 years (range 45-69 years). Age, sex and family history of hearing loss were consistently strong determinants of hearing loss outcomes. After adjusting for these, obesity, current smoking, peripheral arterial disease and history of cardiovascular disease were significantly associated with pure-tone, low-frequency and high-frequency hearing loss. In addition, high blood pressure, triglyceride and glycated haemoglobin were significantly associated with low-frequency hearing loss. There was a graded association between hearing loss and Framingham Risk Score for cardiovascular risk (P<0.001).
Established cardiovascular disease and individual and combined cardiovascular disease risk factors were found to be associated with hearing loss. Future research should prospectively investigate whether targeting cardiovascular disease can prevent hearing loss.
研究听力损失与心血管疾病风险因素之间的关系。
横断面研究。
在2010年5月至2015年12月期间招募参与者，并让他们回答一份健康和风险因素问卷。进行了身体和生化评估。
基于社区的人群。
共有5107名1946年至1964年出生的参与者参加了巴瑟尔顿健康老龄化研究。
通过最佳耳纯音平均听阈（500、1000、2000、4000赫兹）、低频平均听阈（250、500、1000赫兹）和高频平均听阈（4000、8000赫兹）对听力进行行为学评估。通过问卷评估自我报告的听力损失、耳鸣和听觉过敏。通过患者填写的问卷和客观测量，包括血压、体重指数、腰围、血脂谱和糖化血红蛋白，评估心血管风险因素。
参与者中54%为女性，平均年龄58岁（范围45 - 69岁）。年龄、性别和听力损失家族史一直是听力损失结果的强有力决定因素。在对这些因素进行调整后，肥胖、当前吸烟、外周动脉疾病和心血管疾病史与纯音、低频和高频听力损失显著相关。此外，高血压、甘油三酯和糖化血红蛋白与低频听力损失显著相关。听力损失与心血管疾病风险的弗雷明汉风险评分之间存在分级关联（P<0.001）。
已确定心血管疾病以及个体和综合心血管疾病风险因素与听力损失有关。未来的研究应前瞻性地调查针对心血管疾病是否可以预防听力损失。
