Karsenty Gerard
Endocr Pract. 2017 Oct;23(10):1270-1274. doi: 10.4158/EP171966.RA. Epub 2017 Jul 13.
A genetics approach has uncovered that bone has more functions than expected. In particular, bone is an endocrine organ that secretes a growing number of hormones. In that context, the discovery of the osteoblast-derived hormone osteocalcin has significantly broadened the field of bone biology because of the number of physiologic processes regulated by this hormone. At present, osteocalcin has been shown to enhance several aspects of energy metabolism, brain development, and cognition. These discoveries shed light on the cross-talk between multiple organs and provide credence to the search for additional endocrine functions of bone.
ECM = extracellular matrix; Gprc6a = G protein-coupled receptor family C group 6 member A; IL-6 = interleukin-6; WT = wild-type.
遗传学方法已揭示骨骼具有比预期更多的功能。特别是，骨骼是一种内分泌器官，能分泌越来越多的激素。在这种背景下，成骨细胞衍生的激素骨钙素的发现极大地拓宽了骨生物学领域，因为该激素调节着众多生理过程。目前，骨钙素已被证明可增强能量代谢、大脑发育和认知的多个方面。这些发现揭示了多个器官之间的相互作用，并为探寻骨骼的其他内分泌功能提供了依据。
ECM = 细胞外基质；Gprc6a = G蛋白偶联受体家族C组6成员A；IL-6 = 白细胞介素-6；WT = 野生型
