干燥综合征对帕金森病的影响：一项全国性病例对照研究。
Impact of Sjogren's syndrome on Parkinson's disease: A nationwide case-control study.
作者信息
Wu Ming-Chi, Xu Xun, Chen Shan-Ming, Tyan Yeu-Sheng, Chiou Jeng-Yuan, Wang Yu-Hsun, Lin Li-Chi, Chen Chyong-Mei, Wei James Cheng-Chung
机构信息
School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan.
出版信息
PLoS One. 2017 Jul 13;12(7):e0175836. doi: 10.1371/journal.pone.0175836. eCollection 2017.
OBJECTIVE
To investigate whether Sjogren's syndrome would have an influence on the development of Parkinson's disease.
METHODS
A population-based case-control study was conducted. Participants consisted of 7716 subjects with newly diagnosed Parkinson's disease and a population of 75129 matched control subjects between 2000 and 2010. We measured the risk of Parkinson's disease in association with Sjogren's syndrome by using adjusted odds ratios.
RESULTS
A total of 143 Parkinson's disease subjects (1.9%) and 893 control subjects (1.2%) suffered from Sjogren's syndrome (p < 0.001). The crude odds ratio for Parkinson's disease among subjects with Sjogren's syndrome was 1.56 (95% CI 1.30-1.86; p < 0.01). After adjustment for potential confounders which have been proposed that would increase the risk of development of Parkinson's disease, Sjogren's syndrome was found to be significantly associated with the risk of Parkinson's disease with an odds ratio of 1.37 (95% CI 1.15-1.65; p < 0.01).
CONCLUSION
This study preliminarily proposed that Sjogren's syndrome was significant associated with an increased risk of Parkinson's disease.
目的
探讨干燥综合征是否会对帕金森病的发展产生影响。
方法
开展一项基于人群的病例对照研究。参与者包括2000年至2010年间7716例新诊断的帕金森病患者以及75129例匹配的对照人群。我们通过使用调整后的优势比来衡量干燥综合征与帕金森病风险之间的关联。
结果
共有143例帕金森病患者（1.9%）和893例对照者（1.2%）患有干燥综合征（p<0.001）。干燥综合征患者中帕金森病的粗优势比为1.56（95%可信区间1.30 - 1.86；p<0.01）。在对可能增加帕金森病发病风险的潜在混杂因素进行调整后，发现干燥综合征与帕金森病风险显著相关，优势比为1.37（95%可信区间1.15 - 1.65；p<0.01）。
结论
本研究初步提出干燥综合征与帕金森病风险增加显著相关。
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