Zhang Pei, Tian Bo
Department of Neurobiology, Tongji Medical School, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei 430030, China ; Key Laboratory of Neurological Diseases, Ministry of Education, Wuhan, Hubei 430030, China.
Oxid Med Cell Longev. 2014;2014:729194. doi: 10.1155/2014/729194. Epub 2014 May 14.
Metabolic syndrome is becoming commoner due to a rise in obesity rates among adults. Generally speaking, a person with metabolic syndrome is twice as likely to develop cardiovascular disease and five times as likely to develop diabetes as someone without metabolic syndrome. Increasing oxidative stress in metabolic syndrome and Parkinson's disease is mentioned in the comprehensive articles; however, the system review about clear relation between metabolic syndrome and Parkinson's disease is deficient. In this review, we will focus on the analysis that the metabolic syndrome may be a risk factor for Parkinson's disease and the preventions that reduce the incident of Parkinson's disease by regulating the oxidative stress.
由于成年人肥胖率上升，代谢综合征正变得越来越普遍。一般来说，患有代谢综合征的人患心血管疾病的可能性是没有代谢综合征的人的两倍，患糖尿病的可能性是其五倍。综合文章中提到了代谢综合征和帕金森病中氧化应激的增加；然而，关于代谢综合征与帕金森病之间明确关系的系统综述却很缺乏。在本综述中，我们将重点分析代谢综合征可能是帕金森病的一个危险因素，以及通过调节氧化应激来降低帕金森病发病率的预防措施。
