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用于正电子发射断层扫描的敏感生物分子的F标记

F-Labeling of Sensitive Biomolecules for Positron Emission Tomography.

作者信息

Krishnan Hema S, Ma Longle, Vasdev Neil, Liang Steven H

机构信息

Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA.

出版信息

Chemistry. 2017 Nov 7;23(62):15553-15577. doi: 10.1002/chem.201701581. Epub 2017 Sep 1.

DOI:10.1002/chem.201701581
PMID:28704575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5675832/
Abstract

Positron emission tomography (PET) imaging study of fluorine-18 labeled biomolecules is an emerging and rapidly growing area for preclinical and clinical research. The present review focuses on recent advances in radiochemical methods for incorporating fluorine-18 into biomolecules via "direct" or "indirect" bioconjugation. Recently developed prosthetic groups and pre-targeting strategies, as well as representative examples in F-labeling of biomolecules in PET imaging research studies are highlighted.

摘要

氟-18标记生物分子的正电子发射断层扫描（PET）成像研究是临床前和临床研究中一个新兴且快速发展的领域。本综述重点关注通过“直接”或“间接”生物共轭将氟-18引入生物分子的放射化学方法的最新进展。文中突出介绍了最近开发的辅助基团和预靶向策略，以及PET成像研究中生物分子氟标记的代表性实例。

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