钠通道参与灌注肾上腺释放儿茶酚胺的药理学证据。
Pharmacological evidence for the involvement of Na+ channels in the release of catecholamines from perfused adrenal glands.
作者信息
Ito S, Nakazato Y, Ohga A
出版信息
Br J Pharmacol. 1978 Mar;62(3):359-61. doi: 10.1111/j.1476-5381.1978.tb08468.x.
Abstract
Veratridine (0.1 mM) was found to be effective in producing an increase in the catecholamine output from perfused guinea-pig adrenal glands in the presence of high concentrations of hexamethonium (1.83 mM) and atropine (28.8 micrometer). The response to veratridine was abolished by removal of either Na+ or Ca2+ from perfusion media and by the addition of tetrodotoxin (0.1 micrometer). It is suggested that the response to veratridine may be due to an increase in the tetrodotoxin-sensitive Na+ permeability of chromaffin cell membranes.
摘要
发现在高浓度六甲铵（1.83 mM）和阿托品（28.8微摩尔）存在的情况下，藜芦定（0.1 mM）可有效增加灌注豚鼠肾上腺的儿茶酚胺输出量。从灌注介质中去除Na+或Ca2+以及添加河豚毒素（0.1微摩尔）可消除对藜芦定的反应。提示对藜芦定的反应可能是由于嗜铬细胞膜上对河豚毒素敏感的Na+通透性增加所致。
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