Lin Jie, Niu Shubin, Ding Zhengfeng, Wang Renlei, Dai Qun, Wei Wei, Luo Rongrong, Liu Ling
Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry,Jiangsu Second Normal University, Nanjing 210003, China.
School of Biomedicine, Beijing City University, Beijing 100083, China.
Molecules. 2017 Jul 12;22(7):1168. doi: 10.3390/molecules22071168.
Inflatin G (), a new aphidicolin analogue, together with seven known compounds inflatin A (), inflatin B (), aphidicolin (), aphidicolin-17-monoacetate (), gulypyrone A (), pyridoxatin rotamers A () and B (), were isolated from the ascomycete fungus . Their structures were determined through NMR analyses and the circular dichroism data of the in situ formed [Rh₂(OCOCF₃)₄] complexes. Compounds , , , , and showed modest cytotoxicity against four human cancer cell lines A549, CNE1-MP1, A375, and MCF-7.
Inflatin G（），一种新的阿非科林类似物，与七种已知化合物inflatin A（）、inflatin B（）、阿非科林（）、阿非科林-17-单乙酸酯（）、古利普吡喃酮A（）、吡哆菌素旋转异构体A（）和B（）一起，从子囊菌真菌中分离得到。通过核磁共振分析和原位形成的[Rh₂(OCOCF₃)₄]配合物的圆二色性数据确定了它们的结构。化合物、、、、和对四种人类癌细胞系A549、CNE1-MP1、A375和MCF-7表现出适度的细胞毒性。
