唐古特青兰根中的细胞毒萜类化合物。

Cytotoxic Terpenoids from the Roots of Dracocephalum taliense.

机构信息

College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang 110866, China.

出版信息

Molecules. 2017 Dec 27;23(1):57. doi: 10.3390/molecules23010057.

DOI:10.3390/molecules23010057

PMID:29280951

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6017833/

Abstract

A chemical investigation of methanol extract from the roots of led to the isolation of a new aromatic abietane diterpenoid, 12-methoxy-18-hydroxy-sugiol (), and one highly-oxygenated ursane triterpenoid, 2α,3α-dihydroxy-11α,12α-epoxy-urs-28,13β-olide (), together with 15 known natural products (-). Among these, compounds - and - were detected for the first time in the genus of . The structures of all of these isolates were determined by extensively spectroscopic analyses. In the anti-inflammatory assay, compounds and had no obvious inhibitory activity on the release of cytokine IL-2 in lipopolysaccharide-induced RAW 264.7 macrophages. However, compound exhibited significant cytotoxic activity against cell lines HepG2 (IC = 6.58 ± 0.14 μM) and NCI-H1975 (IC = 7.17 ± 0.26 μM).

摘要

从根的甲醇提取物的化学研究导致了一个新的芳香枞烷二萜，12-甲氧基-18-羟基-sugiol ()和一个高度氧化的乌苏烷三萜，2α,3α-二羟基-11α,12α-环氧-urs-28,13β-内酯 ()的分离，以及 15 种已知的天然产物 (-)。其中，化合物-和-首次在属中被检测到。通过广泛的光谱分析确定了所有这些分离物的结构。在抗炎测定中，化合物和对脂多糖诱导的 RAW 264.7 巨噬细胞中细胞因子 IL-2 的释放没有明显的抑制活性。然而，化合物对 HepG2(IC=6.58±0.14μM)和 NCI-H1975(IC=7.17±0.26μM)细胞系表现出显著的细胞毒性活性。