低剂量磷酸钠片与2升聚乙二醇的比较：一项随机研究。
Comparing reduced-dose sodium phosphate tablets to 2 L of polyethylene glycol: A randomized study.
作者信息
Ako Soichiro, Takemoto Koji, Yasutomi Eriko, Sakaguchi Chihiro, Murakami Mayu, Sunami Tomoko, Oka Shohei, Kenta Hamada, Okazaki Noriko, Baba Yuki, Yamasaki Yasushi, Asato Toshiyuki, Kawai Daisuke, Takenaka Ryuta, Tsugeno Hirohumi, Hiraoka Sakiko, Kato Jun, Fujiki Shigeatsu
机构信息
Soichiro Ako, Koji Takemoto, Eriko Yasutomi, Chihiro Sakaguchi, Mayu Murakami, Tomoko Sunami, Shohei Oka, Hamada Kenta, Noriko Okazaki, Yuki Baba, Yasushi Yamasaki, Toshiyuki Asato, Daisuke Kawai, Ryuta Takenaka, Hirohumi Tsugeno, Shigeatsu Fujiki, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama City, Okayama 708-0841, Japan.
出版信息
World J Gastroenterol. 2017 Jun 28;23(24):4454-4461. doi: 10.3748/wjg.v23.i24.4454.
AIM
To compare the tolerability and quality of bowel cleansing between 2 L polyethylene glycol (PEG) and reduced-dose sodium phosphate (NaP) tablets as a preparation for colonoscopy.
METHODS
Two hundred patients were randomly assigned to the PEG or NaP groups at the same ratio. The NaP group patients took 30 tablets with 2 L of clear liquid, while the PEG group patients took 2L of PEG. Tolerability was assessed by a questionnaire about taste, volume, and the overall impression. The bowel cleansing quality was evaluated by colonoscopists.
RESULTS
Although NaP showed better tolerability in terms of taste, volume and overall impression ( < 0.01, < 0.01 and = 0.02, respectively), the overall cleansing quality was better in the PEG group ( < 0.01). A subgroup analysis, stratified by sex and age, indicated that NaP was associated with better tolerability and equivalent bowel cleansing quality in females of < 50 years of age.
CONCLUSION
Despite the better tolerability, the use of 30 NaP tablets with 2 L of clear liquid should be limited due to its lower cleansing quality; however, in certain cases the regimen may deserve consideration, particularly in cases involving young women.
目的
比较2L聚乙二醇（PEG）和低剂量磷酸钠（NaP）片剂用于结肠镜检查肠道准备时的耐受性及肠道清洁质量。
方法
200例患者按相同比例随机分为PEG组或NaP组。NaP组患者服用30片NaP片剂并饮用2L清液，而PEG组患者服用2L PEG。通过关于味道、饮用量和总体印象的问卷评估耐受性。肠道清洁质量由结肠镜检查医师评估。
结果
尽管NaP在味道、饮用量和总体印象方面显示出更好的耐受性（分别为P<0.01、P<0.01和P = 0.02），但PEG组的总体清洁质量更好（P<0.01）。按性别和年龄分层的亚组分析表明，对于年龄<50岁的女性，NaP具有更好的耐受性且肠道清洁质量相当。
结论
尽管耐受性较好，但由于清洁质量较低，服用30片NaP片剂并饮用2L清液的方案应受到限制；然而，在某些情况下该方案可能值得考虑，尤其是涉及年轻女性的情况。
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