Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan.
J Gastroenterol Hepatol. 2012 Oct;27(10):1617-22. doi: 10.1111/j.1440-1746.2012.07190.x.
In Japan, patient acceptance of bowel preparation methods before colonoscopy remains unknown. This study was conducted to evaluate the patient acceptance of sodium phosphate (NaP) tablets and polyethylene glycol solution (PEG) with sodium picosulfate.
One hundred patients were randomized into one of the following two groups: the NaP tablet first-use group or the PEG with sodium picosulfate first-use group in a crossover design trial. Patient acceptance and incidence of adverse events were evaluated using a questionnaire. Colon-cleansing effectiveness was also evaluated.
Patients' overall impressions of the preparations were significantly different between the NaP tablet (77.9%, 67/86) and PEG with sodium picosulfate (60.5%, 52/86; P = 0.001). Nausea incidence as an adverse event was significantly different between the two regimens (P = 0.03). Colon-cleansing effectiveness was not significantly different between the two regimens.
The results of this crossover study showed that patient acceptance was similar to those previously reported in a parallel-group comparison. In Japanese patients, preference for and acceptance of NaP tablets was significantly higher than that for PEG with sodium picosulfate solution.
在日本，接受结肠镜检查前肠道准备方法的患者比例尚不清楚。本研究旨在评估磷酸钠（NaP）片剂和聚乙二醇与匹可硫酸钠溶液（PEG）在日本患者中的接受程度。
采用交叉设计试验，将 100 例患者随机分为 NaP 片剂首用组或 PEG 与匹可硫酸钠溶液首用组。使用问卷评估患者的接受程度和不良反应发生率。同时评估肠道清洁效果。
患者对准备过程的总体印象在 NaP 片剂组（77.9%，67/86）和 PEG 与匹可硫酸钠溶液组（60.5%，52/86）之间有显著差异（P=0.001）。两种方案的恶心发生率也有显著差异（P=0.03）。两种方案的肠道清洁效果无显著差异。
本交叉研究结果表明，患者的接受程度与平行组比较的结果相似。在日本患者中，对 NaP 片剂的偏好和接受程度明显高于 PEG 与匹可硫酸钠溶液。
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