Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
J Dig Dis. 2012 Jul;13(7):374-80. doi: 10.1111/j.1751-2980.2012.00588.x.
The study was aimed to assess the efficacy of sodium phosphate (NaP) tablets and polyethylene glycol (PEG) on colon cleansing.
A prospective, randomized trial was conducted at the Graduate School of Medicine, University of Tokyo. Participants who were scheduled for colonoscopy were included and randomized into either the NaP or PEG group. An interim analysis was programmed into the study design when approximately 50% of the enrolments were completed. The primary outcome was the detection rate of polyps with a diameter ≤5 mm.
A total of 92 patients were included in the analysis, of whom 44 were in the NaP group and 48 in the PEG group. The quality of colonic preparation was similar in both groups. The NaP group showed a higher detection rate of polyps with a diameter ≤5 mm than the PEG group (38.6% vs 18.8%, P = 0.004). A multivariate analysis showed that NaP and the withdrawal time of the colonoscope were independent factors associated with the detection of polyps with a diameter ≤5 mm.
NaP is certainly not inferior to PEG. In fact, the results suggest that diminutive polyp detection using NaP might be superior to that using PEG.
本研究旨在评估磷酸钠（NaP）片和聚乙二醇（PEG）在结肠清洁中的疗效。
这项前瞻性、随机试验在东京大学医学院研究生院进行。纳入计划行结肠镜检查的患者，并将其随机分为 NaP 组或 PEG 组。当大约 50%的入组患者完成时，研究设计中编入了中期分析。主要结局是检测直径≤5mm的息肉的检出率。
共有 92 名患者纳入分析，其中 44 名患者在 NaP 组，48 名患者在 PEG 组。两组的结肠准备质量相似。NaP 组直径≤5mm的息肉检出率高于 PEG 组（38.6% vs 18.8%，P=0.004）。多变量分析显示，NaP 和结肠镜的退出时间是与直径≤5mm的息肉检出相关的独立因素。
NaP 肯定不比 PEG 差。事实上，结果表明使用 NaP 检测微小息肉可能优于使用 PEG。
