Levo Y, Harbeck R J, Kirkpatrick C H
Allergy. 1986 Jan;41(1):26-9. doi: 10.1111/j.1398-9995.1986.tb00270.x.
The effect of histamine and its H1 and H2 antagonists, chlorpheniramine and cimetidine, on the in vitro, PWM-induced, synthesis of IgG and IgE was studied. Histamine had no effect, and cimetidine had a slight inhibitory action. In contrast, chlorpheniramine induced marked suppression of both IgE and IgG synthesis. This effect could not be attributed to drug-induced cytotoxicity. These results suggest that the modulatory effect of histamine on antibody production involves predominantly H1 receptors.
研究了组胺及其H1和H2拮抗剂氯苯那敏和西咪替丁对体外PWM诱导的IgG和IgE合成的影响。组胺无作用，西咪替丁有轻微抑制作用。相反，氯苯那敏可显著抑制IgE和IgG的合成。这种作用不能归因于药物诱导的细胞毒性。这些结果表明，组胺对抗体产生的调节作用主要涉及H1受体。
