Fan Daoqing, Wang Kun, Zhu Jinbo, Xia Yong, Han Yanchao, Liu Yaqing, Wang Erkang
State Key Laboratory of Electroanalytical Chemistry , Changchun Institute of Applied Chemistry , Chinese Academy of Sciences , Changchun , Jilin 130022 , P. R. China . Email:
University of Chinese Academy of Sciences , Beijing , 100039 , China.
Chem Sci. 2015 Mar 1;6(3):1973-1978. doi: 10.1039/c4sc03495c. Epub 2015 Jan 7.
A molecular logic gate is a basic element and plays a key role in molecular computing. Herein, we have developed a label-free and enzyme-free three-input visual majority logic gate which is realized for the first time according to DNA hybridization only, without DNA replacement and enzyme catalysis. Furthermore, a one-vote veto function was integrated into the DNA-based majority logic gate, in which one input has priority over other inputs. The developed system can also implement multiple basic and cascade logic gates.
分子逻辑门是分子计算中的基本元件，起着关键作用。在此，我们开发了一种无标记、无酶的三输入视觉多数逻辑门，该逻辑门首次仅通过DNA杂交实现，无需DNA置换和酶催化。此外，一票否决功能被集成到基于DNA的多数逻辑门中，其中一个输入比其他输入具有更高的优先级。所开发的系统还可以实现多个基本逻辑门和级联逻辑门。
