辛伐他汀局部应用对根尖周缺损骨再生的影响——一项临床影像学研究。
"Effect of local application of simvastatin in bone regeneration of peri-apical defects-a clinico-radiographic study.
作者信息
Gupta Sweety, Verma Promila, Tikku Aseem Prakash, Chandra Anil, Yadav Rakesh Kumar, Bharti Ramesh, Bains Rhythm
机构信息
Conservative Dentistry and Endodontics King George's Medical University, Lucknow, India.
出版信息
J Oral Biol Craniofac Res. 2020 Oct-Dec;10(4):583-591. doi: 10.1016/j.jobcr.2020.08.014. Epub 2020 Aug 29.
OBJECTIVE
The present study evaluates and compares the effectiveness of Simvastatin (SIM), Hydroxyapatite (HA), and platelet-rich fibrin (PRF) in bone regeneration of periapical defects.
MATERIAL& METHOD: Thirty-nine patients were selected and randomized into three groups, Group 1: HA (n = 13), Group 2: PRF (n = 13), Group 3: SIM (n = 13). After completion of RCT and apicoectomy, the grafts were placed locally in the defect and sutured.
RESULTS
At the end of twelve months, postoperative symptoms and radiographic analysis assessed the outcome of the treatment.
CONCLUSION
Intragroup analysis of CBCT- Periapical Index (PAI) scores at 6th and 12th month revealed a significant change in the SIM group (p = 0.018 and 0.001 respectively), compared to PRF (p = 0.026 and 0.001 respectively) and HA (p = 0.053 and 0.039 respectively). Intergroup analysis of change in the level of CBCT-PAI score was highly significant (p = 0.003).SIM caused a more considerable change in the level of CBCT-PAI score compared to other groups, thereby indicating a faster rate of bone regeneration.
目的
本研究评估并比较辛伐他汀（SIM）、羟基磷灰石（HA）和富血小板纤维蛋白（PRF）在根尖周缺损骨再生中的有效性。
材料与方法
选取39例患者并随机分为三组，第1组：HA（n = 13），第2组：PRF（n = 13），第3组：SIM（n = 13）。完成根管治疗和根尖切除术后，将移植物局部置于缺损处并缝合。
结果
在十二个月结束时，通过术后症状和影像学分析评估治疗结果。
结论
对第6个月和第12个月的CBCT根尖指数（PAI）评分进行组内分析发现，与PRF组（分别为p = 0.026和0.001）和HA组（分别为p = 0.053和0.039）相比，SIM组有显著变化（分别为p = 0.018和0.001）。对CBCT-PAI评分水平变化进行组间分析发现差异极显著（p = 0.003）。与其他组相比，SIM使CBCT-PAI评分水平发生了更显著的变化，从而表明其骨再生速度更快。
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