在 25-羟维生素 D 水平低的情况下使用阿托伐他汀和西他列汀导致横纹肌溶解和急性肾损伤。
Rhabdomyolysis and AKI with Atorvastatin and Sitagliptin Use in the Setting of Low 25-Hydroxyvitamin D Levels.
机构信息
Department of Medicine/Nephrology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, 10461, USA.
出版信息
J Gen Intern Med. 2017 Oct;32(10):1156-1159. doi: 10.1007/s11606-017-4115-x. Epub 2017 Jul 13.
Abstract
We report a case of an 86-year-old woman admitted to the hospital with rhabdomyolysis and acute kidney injury 3 weeks after starting sitagliptin while on long-term atorvastatin therapy. She also had low levels of 25-hydroxyvitamin D and mild chronic kidney disease, which may have contributed to the development of rhabdomyolysis. A review of the literature reveals four previous reports of this drug interaction in elderly patients, some with underlying kidney disease.
摘要
我们报告了一例 86 岁女性的病例，她在开始使用西他列汀的 3 周后因横纹肌溶解和急性肾损伤而住院，此前她一直在长期接受阿托伐他汀治疗。她还存在 25-羟维生素 D 水平低和轻度慢性肾脏病，这可能导致了横纹肌溶解的发生。对文献的回顾揭示了此前有四起关于这种药物相互作用的老年患者报告，其中一些患者存在潜在的肾脏疾病。
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本文引用的文献
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Basic Clin Pharmacol Toxicol. 2016 Mar;118(3):214-8. doi: 10.1111/bcpt.12482. Epub 2015 Oct 1.
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Statin Intolerance Because of Myalgia, Myositis, Myopathy, or Myonecrosis Can in Most Cases be Safely Resolved by Vitamin D Supplementation.因肌痛、肌炎、肌病或肌坏死导致的他汀不耐受在大多数情况下可通过补充维生素D安全解决。
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