Padfield N L, Twohig M M, Fraser A C
Br J Anaesth. 1986 May;58(5):487-93. doi: 10.1093/bja/58.5.487.
Temazepam, trimeprazine and placebo were compared as premedication in 85 children undergoing routine otolaryngological operations. Premedication with trimeprazine caused significantly more sedation than temazepam or placebo in patients on arrival in the anaesthetic room (P less than 0.02). Recovery time was significantly longer after trimeprazine than temazepam or placebo (P less than 0.012). Significantly more children (P less than 0.05) failed to recall a picture shown immediately before induction after trimeprazine and temazepam than with placebo. Fewer patients vomited after operation with trimeprazine than with temazepam or placebo (P less than 0.01). The majority of children exhibited some behavioural problem during the first 2 weeks at home, although this rarely lasted for more than a few days. More children exhibited apathetic/withdrawn behaviour after receiving placebo (P less than 0.05), although the significance of this should be interpreted with caution.
对85例接受常规耳鼻喉科手术的儿童，比较了替马西泮、曲美苄嗪和安慰剂作为术前用药的效果。在患儿到达麻醉室时，曲美苄嗪作为术前用药引起的镇静作用明显强于替马西泮或安慰剂（P<0.02）。曲美苄嗪用药后的恢复时间明显长于替马西泮或安慰剂（P<0.012）。与安慰剂相比，曲美苄嗪和替马西泮用药后有明显更多的儿童（P<0.05）无法回忆起诱导前即刻展示的图片。与替马西泮或安慰剂相比，曲美苄嗪用药后术后呕吐的患儿较少（P<0.01）。大多数儿童在术后回家的头2周内出现了一些行为问题，不过这种情况很少持续超过几天。服用安慰剂后有更多儿童表现出冷漠/孤僻行为（P<0.05），不过对此结果的意义应谨慎解读。
