Bailie R, Christmas L, Price N, Restall J, Simpson P, Wesnes K
Department of Anaesthetics, Cambridge Military Hospital, Aldershot.
Br J Anaesth. 1989 Jul;63(1):68-75. doi: 10.1093/bja/63.1.68.
The effects of temazepam 20 mg and placebo were compared for premedication in patients anaesthetized with propofol and alfentanil and undergoing day surgery. Temazepam 20 mg significantly reduced preoperative anxiety and increased recovery time. A series of computerized cognitive tasks revealed significant deficits in attention and memory following anaesthesia, which were increased in range and magnitude by temazepam, which were apparent 30 min after surgery and had largely, but not completely, recovered at 4 h. This study has demonstrated that computerized cognitive testing can identify a wider profile of impairments produced by temazepam than has been found in previous work using non-computerized techniques.
比较了20毫克替马西泮和安慰剂在接受丙泊酚和阿芬太尼麻醉并进行日间手术的患者中作为术前用药的效果。20毫克替马西泮显著降低了术前焦虑并延长了恢复时间。一系列计算机化认知任务显示，麻醉后注意力和记忆力存在明显缺陷，替马西泮使这些缺陷的范围和程度增加，这些缺陷在术后30分钟明显，在4小时时大部分但未完全恢复。这项研究表明，与以往使用非计算机化技术的研究相比，计算机化认知测试能够识别出替马西泮产生的更广泛的损伤情况。
