University of Cambridge, Cambridge, UK.
Angew Chem Int Ed Engl. 2017 Sep 18;56(39):11958-11962. doi: 10.1002/anie.201706303. Epub 2017 Aug 21.
Palladium(II)-catalyzed C-H carbonylation reactions of methylene C-H bonds in secondary aliphatic amines lead to the formation of trans-disubstituted β-lactams in excellent yields and selectivities. The generality of the C-H carbonylation process is aided by the action of xantphos-based ligands and is important in securing good yields for the β-lactam products.
钯（II）催化的仲脂肪族胺中亚甲基 C-H 键的 C-H 羰基化反应以优异的收率和选择性生成反式二取代 β-内酰胺。基于 Xantphos 的配体的作用有助于 C-H 羰基化过程的通用性，并且对于获得良好收率的 β-内酰胺产物很重要。
