a Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
b Department of Midwifery and Reproductive Health, Faculty of Medical Sciences , Tarbiat Modares University , Tehran , Iran.
J Psychosom Obstet Gynaecol. 2018 Dec;39(4):266-272. doi: 10.1080/0167482X.2017.1348496. Epub 2017 Jul 14.
Most reproductive aged women suffer from somatic and mental disorders prior to menstruation. This study investigated whether omega-3 supplement improved premenstrual symptoms and health-related quality of life among reproductive aged women.
A multi-center, balanced (1:1), placebo-controlled, parallel-group randomized clinical trial was conducted in an urban academic institution. A sample consisting of 95 Iranian women aged 20-35 years who were suffering from premenstrual symptoms were randomly allocated into two groups. The treatment consisted of omega-3 supplement containing 1 g fish oil. Placebo was free of oil. The premenstrual symptoms' screening tool and 12-item short form health survey questionnaire were used for data collection.
No statistically significant differences in the baseline characteristics of the groups were reported. Most premenstrual symptoms and their interference with daily activities were significantly reduced over the follow-up period. The mean score of overeating in the omega-3 supplement group and insomnia in the placebo group showed no difference between the groups. The longer use of omega-3 supplement provides improvement of premenstrual symptoms and activities. The mean scores of physical and mental components of quality of life were significantly improved in the omega-3 supplement and placebo groups.
The treatment of premenstrual symptoms using omega-3 supplement reduced symptoms and ameliorated women's quality of life.
大多数育龄期妇女在月经前都会出现躯体和精神障碍。本研究旨在探讨ω-3 补充剂是否能改善育龄期妇女的经前症状和健康相关生活质量。
在城市学术机构中进行了一项多中心、均衡（1:1）、安慰剂对照、平行组随机临床试验。共纳入 95 名有经前症状的伊朗育龄期妇女，年龄 20-35 岁，随机分为两组。治疗组服用含 1g 鱼油的 ω-3 补充剂，安慰剂组不含油。采用经前症状筛查工具和 12 项简短健康调查问卷进行数据收集。
两组基线特征无统计学差异。大多数经前症状及其对日常活动的干扰在随访期间均显著减轻。ω-3 补充组的暴食症状和安慰剂组的失眠症状在组间无差异。ω-3 补充剂使用时间越长，经前症状和活动改善越明显。ω-3 补充剂组和安慰剂组的身体和精神健康相关生活质量的平均分均显著提高。
使用 ω-3 补充剂治疗经前症状可减轻症状，改善妇女的生活质量。
