Department of Clinical Nutrition, Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Biol Trace Elem Res. 2020 Mar;194(1):89-95. doi: 10.1007/s12011-019-01757-9. Epub 2019 Jun 2.
Zinc is known to have multiple beneficial effects including anti-inflammatory and antioxidant and anti-depressant actions. Data on the effects of zinc supplementation on biomarkers of inflammation, oxidative stress, and antidepressant-like effect among young women with premenstrual syndrome (PMS) are scarce. This study was a randomized, double-blind, placebo-controlled trial. Sixty women (18-30 years) with premenstrual syndrome diagnosed according to 30-item questionnaire were randomly assigned to receive either 30-mg zinc gluconate (group 1; n = 30) and/or placebo (group 2; n = 30) for 12 weeks. Premenstrual syndrome symptoms, total antioxidant capacity, high sensitivity reactive protein, and brain-derived neurotrophic factor were measured at study baseline and after 12-week intervention. After 12 weeks of intervention, PMS physical symptoms (P = 0.03) and psychological symptoms (P = 0.006) significantly decreased in zinc group compared to placebo group. We observed a significant increase in brain-derived neurotrophic factor (P = 0.01) and total antioxidant capacity (P ˂ 0.001) after 12 weeks of intervention with zinc compared to placebo. We failed to find any significant effect of zinc supplementation on high sensitivity reactive protein. Overall, zinc supplementation for 12 weeks among women with premenstrual syndrome had beneficial effects on physical and psychological symptoms of premenstrual syndrome, total antioxidant capacity, and brain-derived neurotrophic factor.
锌具有多种有益作用，包括抗炎、抗氧化和抗抑郁作用。关于补锌对经问卷调查确诊为经前期综合征（PMS）的年轻女性的炎症生物标志物、氧化应激和抗抑郁样作用的影响的数据很少。本研究为一项随机、双盲、安慰剂对照试验。将 60 名（18-30 岁）经 30 项问卷确诊为经前期综合征的女性随机分为两组，分别接受 30 毫克葡萄糖酸锌（组 1；n = 30）和/或安慰剂（组 2；n = 30）治疗 12 周。在研究基线和 12 周干预后测量经前期综合征症状、总抗氧化能力、高敏 C 反应蛋白和脑源性神经营养因子。经过 12 周的干预，与安慰剂组相比，锌组的经前期综合征躯体症状（P = 0.03）和心理症状（P = 0.006）显著下降。与安慰剂相比，我们观察到锌干预 12 周后脑源性神经营养因子（P = 0.01）和总抗氧化能力（P ˂ 0.001）显著增加。我们未能发现补锌对高敏 C 反应蛋白有任何显著影响。总的来说，锌补充剂治疗经前期综合征女性 12 周对经前期综合征的躯体和心理症状、总抗氧化能力和脑源性神经营养因子有有益影响。
