Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
IRCCS Neuromed, Pozzilli, Italy.
Curr Neuropharmacol. 2018;16(5):636-643. doi: 10.2174/0929867324666170713103621.
Glioblastoma is the most aggressive and deadly brain tumor, with low disease-free period even after surgery and combined radio and chemotherapies. Among the factors contributing to the devastating effect of this tumor in the brain are the elevated proliferation and invasion rate, and the ability to induce a local immunosuppressive environment. The intermediateconductance Ca2+-activated K+ channel KCa3.1 is expressed in glioblastoma cells and in tumorinfiltrating cells.
We first describe the researches related to the role of KCa3.1 channels in the invasion of brain tumor cells and the regulation of cell cycle. In the second part we review the involvement of KCa3.1 channel in tumor-associated microglia cell behaviour.
In tumor cells, the functional expression of KCa3.1 channels is important to substain cell invasion and proliferation. In tumor infiltrating cells, KCa3.1 channel activity is required to regulate their activation state. Interfering with KCa3.1 activity can be an adjuvant therapeutic approach in addition to classic chemotherapy and radiotherapy, to counteract tumor growth and prolong patient's survival.
In this mini-review we discuss the evidence of the functional roles of KCa3.1 channels in glioblastoma biology.
胶质母细胞瘤是最具侵袭性和致命性的脑肿瘤，即使在手术后联合放射和化疗，疾病无进展期也很短。导致这种肿瘤在大脑中具有破坏性影响的因素包括增殖和侵袭率升高，以及诱导局部免疫抑制环境的能力。中电导钙激活钾通道 KCa3.1 表达于胶质母细胞瘤细胞和肿瘤浸润细胞中。
我们首先描述了 KCa3.1 通道在脑肿瘤细胞侵袭和细胞周期调控中的作用的相关研究。在第二部分，我们综述了 KCa3.1 通道在肿瘤相关小胶质细胞行为中的作用。
在肿瘤细胞中，KCa3.1 通道的功能表达对于维持细胞侵袭和增殖至关重要。在肿瘤浸润细胞中，KCa3.1 通道的活性对于调节其激活状态是必需的。干扰 KCa3.1 活性可以作为经典化疗和放疗的辅助治疗方法，以对抗肿瘤生长并延长患者的生存时间。
在这篇迷你综述中，我们讨论了 KCa3.1 通道在胶质母细胞瘤生物学中的功能作用的证据。
