a Abteilung für Molekulare Genetik, Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften (GZMB), Georg-August Universität Göttingen , Göttingen , Germany.
RNA Biol. 2017 Dec 2;14(12):1642-1648. doi: 10.1080/15476286.2017.1345835. Epub 2017 Jul 31.
Understanding the mechanisms for mRNA production under normal conditions and in response to cytotoxic stresses has been subject of numerous studies for several decades. The shutdown of canonical mRNA transcription, export and translation is required to have enough free resources for the immediate production of heat shock proteins that act as chaperones to sustain cellular processes. In recent work we uncovered a simple mechanism, in which the export block of regular mRNAs and a fast export of heat shock mRNAs is achieved by deactivation of the nuclear mRNA quality control mediated by the guard proteins. In this point of view we combine long known data with recently gathered information that support this novel model, in which cells omit quality control of stress responsive transcripts to ensure survival.
几十年来，人们对正常条件下和应对细胞毒性应激时的 mRNA 产生机制进行了大量研究。需要关闭规范的 mRNA 转录、输出和翻译，以便有足够的自由资源来立即产生热休克蛋白，这些蛋白作为伴侣来维持细胞过程。在最近的工作中，我们发现了一种简单的机制，通过失活由守护蛋白介导的核 mRNA 质量控制，实现了常规 mRNAs 的输出阻断和热休克 mRNAs 的快速输出。在这个观点中，我们将长期已知的数据与最近收集的支持这一新型模型的信息结合起来，即细胞忽略应激反应转录物的质量控制以确保生存。
