Makary Raafat F, Gopinath Arun, Markiewicz Michael R, Fernandes Rui
Soft Tissue Pathology, Neuropathology and Autopsy Services, Department of Pathology and Laboratory Medicine, University of Florida College of Medicine, University of Florida, Jacksonville, 655 West 8th Street, Box C-504, Jacksonville, FL 32209-6511, USA.
Head and Neck Pathology, Department of Pathology and Laboratory Medicine, University of Florida College of Medicine, University of Florida, Jacksonville, 655 West 8th Street, Box C-504, Jacksonville, FL 32209-6511, USA.
Oral Maxillofac Surg Clin North Am. 2017 Aug;29(3):355-366. doi: 10.1016/j.coms.2017.04.002.
Head and neck sarcomas are rare but are associated with significant morbidity/mortality and management difficulties. These tumors are best managed in a multidisciplinary setting. Open or core biopsy is essential for histologic diagnosis and grading. Complete surgical tumor resection with negative margins at the first attempt is the best chance for potential cure. In most patients, except those with small resectable low-grade lesions, adjuvant radiotherapy and chemotherapy are added to maximize local control with variable results. Resection margins effect on recurrence rate and treatment modalities in selective types of head and neck sarcomas are discussed in this article.
头颈部肉瘤罕见,但与显著的发病率/死亡率及治疗困难相关。这些肿瘤最好在多学科环境中进行管理。开放活检或芯针活检对于组织学诊断和分级至关重要。首次尝试时完整切除肿瘤且切缘阴性是实现潜在治愈的最佳机会。在大多数患者中,除了那些可切除的小的低级别病变患者外,均需加用辅助放疗和化疗以最大程度地实现局部控制,但效果各异。本文讨论了切缘对选择性头颈部肉瘤类型的复发率和治疗方式的影响。