Assadi Alireza, Berjis Nezamoddin, Motamedi Narges, Eshaghian Afrooz
Department of Otorhinolaryngology, school of Medicine, Kashani University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community and Family Medicine, school of Medicine, Social Determinants of Health Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Iran J Otorhinolaryngol. 2024 Jul;36(4):537-543. doi: 10.22038/IJORL.2024.75749.3535.
Head and neck sarcomas are uncommon tumors that account for less than 1% of head and neck malignancies and fewer than 5% of all sarcomas. This study aims to assess the head and neck sarcomas pattern in Isfahan, Iran, compare its results with previous findings, and investigate treatment methods and the recurrence and survival rate.
This study was done on 160 patients diagnosed with head and neck sarcomas between 2001 and 2020 in four medical centers in Isfahan, Iran. The patients with head and neck sarcoma confirmed by biopsy were included. Patient information included sex, age at diagnosis, and full characteristics of the mass. Disease recurrence and 2-year and 5-year overall survival (OS) were investigated by phone.
Among 160 patients, 94 (58.8%) were male. The mean age was 36.9 ± 23.2 years. The neck was the most reported location for sarcomas (N=34, 21.3%). Undifferentiated pleomorphic sarcoma was the most frequent histopathologic pattern (N=48, 30.0%). The brain and lungs were the most common destinations for metastasis. "Surgery and adjuvant therapy together" was the most common type of treatment (N=108, 68.8%). The 2-year and 5-year recurrence rates were N=100, 62.5%, and N=110, 68.8%, respectively. The 2-year and 5-year OS was N=103, 64.4%, and N=58, 36.6%, respectively. Eighty-nine patients have had metastasis (55.6%).
Both 2-year and 5-year recurrence rates and OS were significantly correlated with metastasis. The OS within two years and five years were significantly higher in those treated only by "Surgery".
头颈部肉瘤是罕见肿瘤，占头颈部恶性肿瘤的比例不到1%，占所有肉瘤的比例不到5%。本研究旨在评估伊朗伊斯法罕的头颈部肉瘤模式，将其结果与先前的研究结果进行比较，并调查治疗方法以及复发率和生存率。
本研究对2001年至2020年期间在伊朗伊斯法罕的四个医疗中心确诊为头颈部肉瘤的160例患者进行。纳入经活检确诊为头颈部肉瘤的患者。患者信息包括性别、诊断时的年龄以及肿块的全部特征。通过电话调查疾病复发情况以及2年和5年总生存率（OS）。
160例患者中，94例（58.8%）为男性。平均年龄为36.9±23.2岁。颈部是肉瘤最常报道的部位（n=34，21.3%）。未分化多形性肉瘤是最常见的组织病理学模式（n=48，30.0%）。脑和肺是最常见的转移部位。“手术联合辅助治疗”是最常见的治疗类型（n=108，68.8%）。2年和5年复发率分别为n=100（62.5%）和n=110（68.8%）。2年和5年总生存率分别为n=103（64.4%）和n=58（36.6%）。89例患者发生了转移（55.6%）。
2年和5年复发率及总生存率均与转移显著相关。仅接受“手术”治疗的患者在两年和五年内的总生存率显著更高。
