Division of Mental Health and Addiction, Vestfold Hospital Trust, Tønsberg, Norway.
Division of Mental Health and Addiction, Vestfold Hospital Trust, Tønsberg, Norway; Department of Psychology, University of Oslo, Oslo, Norway.
Schizophr Res. 2018 Mar;193:418-422. doi: 10.1016/j.schres.2017.07.015. Epub 2017 Jul 11.
Schizophrenia is associated with reduced cardio-respiratory fitness (CRF), and impaired cognition is a core feature of the disorder. Despite their particular significance to schizophrenia disparately, the relationship between these two variables has not yet been thoroughly assessed. In this study we aimed to investigate naturally occurring associations between CRF and all cognitive domains within this patient population.
Eighty outpatients with schizophrenia spectrum disorders participated in the study. Neurocognition was assessed with the Wechsler Adult Intelligence Scale version 4 General Ability Index (WAIS GAI) and the MATRICS Consensus Cognitive Battery (MCCB). Oxygen uptake was measured directly by analyzing O and CO content in expired air during a maximum exercise session on a treadmill using a modified Balke protocol. Clinical symptom load was assessed with the Positive and Negative Syndrome Scale (PANSS). Hierarchical multiple regression analyses were conducted, controlling for sex and age, and negative psychotic symptom levels.
CRF explained a significant 8.2% and 9.1% of the variance in general intellectual ability and state-sensitive cognitive functioning respectively, beyond the impact of negative psychotic symptom load.
The study indicates a direct relation between CRF and cognition in schizophrenia. Impaired cognition is a difficult-to-treat expression of the disorder, and identifying modifiable factors possibly mediating cognition, such as CRF, is of great clinical value.
精神分裂症与心肺功能适应性（CRF）降低有关，认知障碍是该疾病的核心特征。尽管它们对精神分裂症具有特殊意义，但这两个变量之间的关系尚未得到彻底评估。在这项研究中，我们旨在调查该患者群体中 CRF 与所有认知领域之间自然存在的关联。
80 名患有精神分裂症谱系障碍的门诊患者参与了这项研究。使用韦氏成人智力量表第 4 版一般能力指数（WAIS GAI）和 MATRICS 共识认知电池（MCCB）评估神经认知。通过使用改良的 Balke 方案在跑步机上进行最大运动期间分析呼出空气中的 O 和 CO 含量，直接测量耗氧量。使用阳性和阴性症状量表（PANSS）评估临床症状负荷。进行了层次多重回归分析，控制了性别和年龄以及阴性精神病症状水平的影响。
CRF 分别解释了一般智力和状态敏感认知功能的 8.2%和 9.1%的方差，超出了阴性精神病症状负荷的影响。
该研究表明精神分裂症中 CRF 与认知之间存在直接关系。认知障碍是该疾病难以治疗的表现，识别可能介导认知的可调节因素，如 CRF，具有重要的临床价值。
