Division of Mental Health and Addiction, Vestfold Hospital Trust, Tønsberg, Norway.
Division of Mental Health and Addiction, Vestfold Hospital Trust, Tønsberg, Norway.
Schizophr Res. 2019 Apr;206:157-162. doi: 10.1016/j.schres.2018.11.033. Epub 2018 Dec 7.
We investigated whether the relationship between cardio-respiratory fitness (CRF) and cognition in schizophrenia is general, or due to selective relationships between CRF and specific aspects of cognitive function.
Eighty outpatients with schizophrenia spectrum disorders participated. Neurocognition was assessed with the Wechsler Adult Intelligence Scale version 4 General Ability Index (WAIS GAI), the MATRICS Consensus Cognitive Battery (MCCB) and the Emotion in Biological Motion (EBM) test. CRF was assessed with peak oxygen uptake measured directly during maximum exercise using a modified Balke protocol. Partial correlations, controlling for sex and age, were obtained for the perceptual and the verbal indices of WAIS GAI, six cognitive domains of MCCB, and the EBM total score. A factor analysis was conducted on all 15 subtests of the WAIS GAI and the MCCB, and the factors were subjected to separate regression analyses with CRF as predictor.
Significant, moderately sized correlations were found between CRF and all cognitive domains except processing speed. The correlation appeared strongest for CRF and the Verbal Comprehension Index of WAIS GAI (r = 0.29, p = .005). The factor analysis identified three factors: one speed/attention/executive function factor, one verbal factor, and one perceptual factor. Regression analyses showed that VO explained a significant amount of variance in the verbal factor only (R = 0.06, β = 0.329, p = .03).
The results indicate that the relationship between CRF and cognition in schizophrenia is selectively tied to a modality-specific association with verbal cognitive abilities. These findings have implications for understanding the relation between cognitive factors and physical health in schizophrenia. ClinicalTrials.gov reg. number NCT02205684 (clinicaltrials.gov/ct2/show/NCT02205684).
我们旨在探究精神分裂症患者的心肺功能（CRF）与认知之间的关系是普遍存在的，还是仅存在于 CRF 与特定认知功能领域之间的特定关系。
共纳入 80 名精神分裂症谱系障碍患者。神经认知功能采用韦氏成人智力量表第四版一般能力指数（WAIS GAI）、认知能力成套测验（MCCB）和生物运动情绪（EBM）测验进行评估。CRF 通过改良的 Balke 方案在最大运动期间直接测量最大摄氧量进行评估。采用偏相关分析，控制性别和年龄，对 WAIS GAI 的知觉和言语指标、MCCB 的六个认知领域以及 EBM 总分进行分析。对 WAIS GAI 和 MCCB 的所有 15 个分测验进行因子分析，将 CRF 作为预测因子对因子进行回归分析。
CRF 与除加工速度外的所有认知领域均呈显著中度相关。CRF 与 WAIS GAI 的言语理解指数相关性最强（r=0.29，p=0.005）。因子分析确定了三个因子：一个速度/注意力/执行功能因子、一个言语因子和一个知觉因子。回归分析表明，VO 仅能解释言语因子的显著差异（R=0.06，β=0.329，p=0.03）。
结果表明，精神分裂症患者 CRF 与认知之间的关系选择性地与言语认知能力的特定关联有关。这些发现对理解精神分裂症患者认知因素与身体健康之间的关系具有重要意义。临床试验注册号 NCT02205684（clinicaltrials.gov/ct2/show/NCT02205684）。
