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Uncovering novel roles for matrix metalloproteinases in preeclampsia.

作者信息

Foote Christopher A, Martinez-Lemus Luis A

机构信息

Dalton Cardiovascular Research Center and Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri.

Dalton Cardiovascular Research Center and Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri

出版信息

Am J Physiol Heart Circ Physiol. 2017 Oct 1;313(4):H687-H689. doi: 10.1152/ajpheart.00374.2017. Epub 2017 Jul 14.

DOI:10.1152/ajpheart.00374.2017
PMID:28710071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6148087/
Abstract
摘要

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Uncovering novel roles for matrix metalloproteinases in preeclampsia.揭示基质金属蛋白酶在子痫前期中的新作用。
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2
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[Expression of trophoblast invasion related genes mRNA and protein in human placenta in preeclampsia].子痫前期患者胎盘滋养细胞侵袭相关基因mRNA和蛋白的表达
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Placental growth factor reverses decreased vascular and uteroplacental MMP-2 and MMP-9 and increased MMP-1 and MMP-7 and collagen types I and IV in hypertensive pregnancy.胎盘生长因子可逆转高血压妊娠中血管和胎盘基质金属蛋白酶-2 和基质金属蛋白酶-9 的减少，以及基质金属蛋白酶-1 和基质金属蛋白酶-7 和 I 型和 IV 型胶原的增加。
Am J Physiol Heart Circ Physiol. 2018 Jul 1;315(1):H33-H47. doi: 10.1152/ajpheart.00045.2018. Epub 2018 Mar 23.
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Matrix metalloproteinases: control of vascular function and their potential role in preeclampsia.基质金属蛋白酶：血管功能的调控及其在子痫前期中的潜在作用
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Increased urinary levels of podocyte glycoproteins, matrix metallopeptidases, inflammatory cytokines, and kidney injury biomarkers in women with preeclampsia.子痫前期女性尿中足细胞糖蛋白、基质金属肽酶、炎性细胞因子和肾损伤生物标志物水平升高。
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Lack of an association of a single nucleotide polymorphism in the promoter of the matrix metalloproteinase-1 gene in Czech women with pregnancy-induced hypertension.捷克患有妊娠高血压综合征的女性中，基质金属蛋白酶-1基因启动子区单核苷酸多态性缺乏相关性。
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Expression of Matrix Metalloproteinase-2,-7,-9 in Serum during Pregnancy in Patients with Pre-Eclampsia: A Prospective Study.基质金属蛋白酶-2、-7、-9 在子痫前期患者妊娠期间血清中的表达：一项前瞻性研究。
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本文引用的文献

1
Increased vascular and uteroplacental matrix metalloproteinase-1 and -7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-α.妊娠期高血压疾病中血管及子宫胎盘基质金属蛋白酶-1和-7水平升高以及I型胶原沉积：肿瘤坏死因子-α的作用
Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H491-H507. doi: 10.1152/ajpheart.00207.2017. Epub 2017 Jun 16.
2
Reduced uterine perfusion pressure T-helper 17 cells cause pathophysiology associated with preeclampsia during pregnancy.子宫灌注压降低时，辅助性T细胞17会引发与妊娠期先兆子痫相关的病理生理过程。
Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1192-R1199. doi: 10.1152/ajpregu.00117.2016. Epub 2016 Oct 26.
3
Regional variation in arterial stiffening and dysfunction in Western diet-induced obesity.西方饮食诱导肥胖中动脉僵硬度和功能障碍的区域差异。
Am J Physiol Heart Circ Physiol. 2015 Aug 15;309(4):H574-82. doi: 10.1152/ajpheart.00155.2015. Epub 2015 Jun 19.
4
Arterial stiffening precedes systolic hypertension in diet-induced obesity.动脉僵硬度在饮食诱导肥胖引起的收缩期高血压之前出现。
Hypertension. 2013 Dec;62(6):1105-10. doi: 10.1161/HYPERTENSIONAHA.113.01744. Epub 2013 Sep 23.
5
Maternal uterine vascular remodeling during pregnancy.孕期母体子宫血管重塑。
Microcirculation. 2014 Jan;21(1):38-47. doi: 10.1111/micc.12080.
6
Doxycycline ameliorates 2K-1C hypertension-induced vascular dysfunction in rats by attenuating oxidative stress and improving nitric oxide bioavailability.多西环素通过减轻氧化应激和提高一氧化氮生物利用度改善 2K-1C 高血压诱导的血管功能障碍。
Nitric Oxide. 2012 Mar 31;26(3):162-8. doi: 10.1016/j.niox.2012.01.009. Epub 2012 Feb 3.
7
ADAM17 regulates TNFα production by placental trophoblasts.ADAM17 调节胎盘滋养层细胞 TNFα 的产生。
Placenta. 2011 Dec;32(12):975-80. doi: 10.1016/j.placenta.2011.09.015. Epub 2011 Oct 20.
8
Human decidua and invasive trophoblasts are rich sources of nearly all human matrix metalloproteinases.人蜕膜和侵袭性滋养层是几乎所有人类基质金属蛋白酶的丰富来源。
Mol Hum Reprod. 2011 Oct;17(10):637-52. doi: 10.1093/molehr/gar033. Epub 2011 May 12.
9
Inward remodeling of resistance arteries requires reactive oxygen species-dependent activation of matrix metalloproteinases.阻力血管的内向重构需要依赖活性氧物质激活的基质金属蛋白酶。
Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2005-15. doi: 10.1152/ajpheart.01066.2010. Epub 2011 Apr 1.
10
Longitudinal modulation of immune system cytokine profile during pregnancy.妊娠期间免疫系统细胞因子谱的纵向调节。
Cytokine. 2011 Feb;53(2):170-7. doi: 10.1016/j.cyto.2010.11.005. Epub 2010 Nov 30.