文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

Clinical features and treatment response of cutaneous leishmaniasis in North-West Ethiopia.

作者信息

Fikre Helina, Mohammed Rezika, Atinafu Saba, van Griensven Johan, Diro Ermias

机构信息

Leishmaniasis Research and Treatment Center, University of Gondar, Gondar, Ethiopia.

Department of Internal Medicine, University of Gondar, Gondar, Ethiopia.

出版信息

Trop Med Int Health. 2017 Oct;22(10):1293-1301. doi: 10.1111/tmi.12928. Epub 2017 Aug 13.


DOI:10.1111/tmi.12928
PMID:28712122
Abstract

OBJECTIVE: Cutaneous leishmaniasis (CL) receives far less attention than visceral leishmaniasis. Nevertheless, CL is predominantly caused by a unique species in Ethiopia (L. aethiopica), which is known to cause severe forms such as diffuse (DCL) and mucocutaneous leishmaniasis (MCL). We report on the number and type of CL cases diagnosed, the clinical features, the treatments and treatment outcomes in North-West Ethiopia. METHODS: This is a retrospective chart record analysis of CL patients treated at the Leishmania Research and Treatment Center (LRTC) of the University of Gondar, Ethiopia. RESULTS: From 178 CL patients seen between January 2014 and December 2015, a total of 154 chart records were retrieved. These included 80 localised CL (LCL), 7 DCL and 67 MCL. The median age was 23 years; 71.4% were male. Most (n = 121, 78.6%) of the lesions were on the face. The median time since onset was 12 months (6-24 months), and 28.6% presented after a trial of traditional medicine. The treatment of all forms of CL mainly consisted of 30 days of IM antimonial injections. Of these, 51/133 (38.3%) required treatment extension or change due to nonresponse. Three cases were treated with liposomal amphotericin B or miltefosine (two received the combination), of which two responded well. CONCLUSION: CL was found to be complicated and difficult to treat. MCL was common, and patients presented after long delays. There is an urgent need to look for better treatment options for CL and improve access to care.

摘要

相似文献

[1]
Clinical features and treatment response of cutaneous leishmaniasis in North-West Ethiopia.

Trop Med Int Health. 2017-10

[2]
Treatment of Cutaneous Leishmaniasis Caused by Leishmania aethiopica: A Systematic Review.

PLoS Negl Trop Dis. 2016-3-3

[3]
Treatment response of cutaneous leishmaniasis due to Leishmania aethiopica to cryotherapy and generic sodium stibogluconate from patients in Silti, Ethiopia.

Trans R Soc Trop Med Hyg. 2012-4-12

[4]
Demographic characteristics and clinical features of patients presenting with different forms of cutaneous leishmaniasis, in Lay Gayint, Northern Ethiopia.

PLoS Negl Trop Dis. 2024-8

[5]
Liposomal amphotericin B in travelers with cutaneous and muco-cutaneous leishmaniasis: Not a panacea.

PLoS Negl Trop Dis. 2017-11-20

[6]
Susceptibility of clinical isolates of Leishmania aethiopica to miltefosine, paromomycin, amphotericin B and sodium stibogluconate using amastigote-macrophage in vitro model.

Exp Parasitol. 2013-2-19

[7]
Leishmania (Kinetoplastida): species typing with isoenzyme and PCR-RFLP from cutaneous leishmaniasis patients in Ethiopia.

Exp Parasitol. 2007-4

[8]
[A multifocal form of cutaneous leishmaniasis caused by Leishmania infantum in an immunocompetent child treated with a short course of liposomal amphotericin B].

Ann Dermatol Venereol. 2016-10

[9]
Miltefosine for the treatment of cutaneous leishmaniasis-A pilot study from Ethiopia.

PLoS Negl Trop Dis. 2021-5

[10]
Leishmaniasis recidivans in Ethiopia: cutaneous and mucocutaneous features.

J Infect Dev Ctries. 2017-1-30

引用本文的文献

[1]
Ambiguities in cutaneous leishmaniasis classification and the need for consensus: Experience from Ethiopia.

PLoS Negl Trop Dis. 2025-8-22

[2]
Spatial Epidemiology of Clinical Forms of Cutaneous Leishmaniasis and Treatment Practice: Evidence from Leishmaniasis Research and Treatment Center, Northwest Ethiopia.

Iran J Parasitol. 2025

[3]
Outbreak of cutaneous leishmaniasis amongst militia members in a non-endemic district under conflict in the lowlands of Somali Region caused by Leishmania tropica, Eastern Ethiopia.

PLoS Negl Trop Dis. 2025-7-22

[4]
Double-triangular flap for reconstruction of a circular skin defect in the central frontal region.

Dermatol Reports. 2025-2-6

[5]
Epidemiological and clinical profiles of cutaneous leishmaniasis cases in Amhara National Regional State, Northwest Ethiopia: a multicenter retrospective study.

Dermatol Reports. 2025-2-6

[6]
Protocol for a prospective observational cohort study of cutaneous leishmaniasis in Ethiopia.

NIHR Open Res. 2024-12-3

[7]
Prevalence and risk factors of cutaneous leishmaniasis in a newly identified endemic site in South-Ethiopia.

PLoS One. 2024-12-30

[8]
Clinical pattern and treatment outcome of cutaneous leishmaniasis patients in Somali region, eastern Ethiopia.

Skin Health Dis. 2024-6-30

[9]
Case Notification of Cutaneous Leishmaniasis at Different Elevations in the North-Central Ethiopia from 2018 To 2022.

Iran J Parasitol. 2024

[10]
Demographic characteristics and clinical features of patients presenting with different forms of cutaneous leishmaniasis, in Lay Gayint, Northern Ethiopia.

PLoS Negl Trop Dis. 2024-8

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索