• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Watching the gorilla and questioning delivery dogma.

作者信息

Anchordoquy Thomas J, Simberg Dmitri

机构信息

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

出版信息

J Control Release. 2017 Sep 28;262:87-90. doi: 10.1016/j.jconrel.2017.07.021. Epub 2017 Jul 14.

DOI:10.1016/j.jconrel.2017.07.021
PMID:28713040
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5662108/
Abstract
摘要

相似文献

1
Watching the gorilla and questioning delivery dogma.观察大猩猩并质疑分娩教条。
J Control Release. 2017 Sep 28;262:87-90. doi: 10.1016/j.jconrel.2017.07.021. Epub 2017 Jul 14.
2
Effect of polymer architecture on curcumin encapsulation and release from PEGylated polymer nanoparticles: Toward a drug delivery nano-platform to the CNS.聚合物结构对姜黄素包封及从聚乙二醇化聚合物纳米粒中释放的影响：迈向中枢神经系统药物递送纳米平台
Eur J Pharm Biopharm. 2015 Oct;96:409-20. doi: 10.1016/j.ejpb.2015.09.004. Epub 2015 Sep 25.
3
PEGylated hyperbranched polyphosphoester based nanocarriers for redox-responsive delivery of doxorubicin.基于聚乙二醇化超支化聚磷酸酯的纳米载体用于阿霉素的氧化还原响应递送
Biomater Sci. 2016 Mar;4(3):412-7. doi: 10.1039/c5bm00440c.
4
Factors affecting drug encapsulation and stability of lipid-polymer hybrid nanoparticles.影响载药脂质-聚合物杂化纳米粒包封率和稳定性的因素。
Colloids Surf B Biointerfaces. 2011 Jul 1;85(2):214-20. doi: 10.1016/j.colsurfb.2011.02.033. Epub 2011 Mar 2.
5
Lysozyme-loaded lipid-polymer hybrid nanoparticles: preparation, characterization and colloidal stability evaluation.载溶菌酶脂质-聚合物杂化纳米粒：制备、表征及胶体稳定性评估
Drug Dev Ind Pharm. 2016 Nov;42(11):1865-76. doi: 10.1080/03639045.2016.1180392. Epub 2016 Apr 28.
6
Nanoscale Lipophilic Prodrugs of Dexamethasone with Enhanced Pharmacokinetics.具有增强药代动力学的地塞米松的纳米级亲脂前药。
Mol Pharm. 2019 Jul 1;16(7):2999-3010. doi: 10.1021/acs.molpharmaceut.9b00237. Epub 2019 Jun 4.
7
Fabrication of particulate reservoir-containing, capsulelike, and self-folding polymer microstructures for drug delivery.用于药物递送的含颗粒储库、胶囊状和自折叠聚合物微结构的制造。
Small. 2007 Mar;3(3):412-8. doi: 10.1002/smll.200600240.
8
Development and characterization of gemcitabine hydrochloride loaded lipid polymer hybrid nanoparticles (LPHNs) using central composite design.采用中心复合设计研制并评价盐酸吉西他滨载药脂质聚合物杂化纳米粒（LPHNs）。
Int J Pharm. 2018 Sep 5;548(1):255-262. doi: 10.1016/j.ijpharm.2018.06.063. Epub 2018 Jun 30.
9
Effects of poly(ethylene glycol) grafting density on the tumor targeting efficacy of nanoparticles with ligand modification.聚乙二醇接枝密度对配体修饰纳米颗粒肿瘤靶向疗效的影响。
Drug Deliv. 2015 Feb;22(2):182-90. doi: 10.3109/10717544.2013.854849. Epub 2013 Nov 12.
10
Nanoparticles based on a hydrophilic polyester with a sheddable PEG coating for protein delivery.基于具有可脱落聚乙二醇涂层的亲水性聚酯的纳米颗粒用于蛋白质递送。
Pharm Res. 2014 Oct;31(10):2593-604. doi: 10.1007/s11095-014-1355-x. Epub 2014 Mar 14.

引用本文的文献

1
Artificial intelligence in drug development: reshaping the therapeutic landscape.药物研发中的人工智能：重塑治疗格局。
Ther Adv Drug Saf. 2025 Feb 24;16:20420986251321704. doi: 10.1177/20420986251321704. eCollection 2025.
2
Characteristics of the Antitumor Effect of Doxorubicin and Pegylated Hyaluronidase on Models of Rat Brain Tumors.多柔比星和聚乙二醇化透明质酸酶对大鼠脑肿瘤模型抗肿瘤作用的特点。
Bull Exp Biol Med. 2024 May;177(1):147-154. doi: 10.1007/s10517-024-06147-3. Epub 2024 Jul 4.
3
Revisiting the outstanding questions in cancer nanomedicine with a future outlook.展望未来，重新审视癌症纳米医学中的突出问题。
Nanoscale Adv. 2021 Dec 22;4(3):634-653. doi: 10.1039/d1na00810b. eCollection 2022 Feb 1.
4
The Effect of Repeat Administration of Lipoplexes on Gene Delivery, Biodistribution, and Cytokine Response in Immunocompetent Tumor-Bearing Mice.脂质体重复给药对免疫功能正常荷瘤小鼠基因传递、生物分布和细胞因子反应的影响。
J Pharm Sci. 2022 Jul;111(7):1926-1936. doi: 10.1016/j.xphs.2021.12.017. Epub 2021 Dec 18.
5
Lipid nanoparticle formulation of niclosamide (nano NCM) effectively inhibits SARS-CoV-2 replication .氯硝柳胺脂质纳米颗粒制剂（纳米NCM）可有效抑制新型冠状病毒（SARS-CoV-2）的复制。
Precis Nanomed. 2021 Apr 17;4(1):724-737. doi: 10.33218/001c.18813. Epub 2021 Jan 17.
6
Phosphatidylinositol Stabilizes Fluid-Phase Liposomes Loaded with a Melphalan Lipophilic Prodrug.磷脂酰肌醇可稳定负载美法仑亲脂性前药的液相脂质体。
Pharmaceutics. 2021 Apr 1;13(4):473. doi: 10.3390/pharmaceutics13040473.
7
The Use of Lactose as an Alternative Coating for Nanoparticles.乳糖作为纳米粒子替代包衣的应用。
J Pharm Sci. 2020 Apr;109(4):1573-1580. doi: 10.1016/j.xphs.2020.01.019. Epub 2020 Jan 28.
8
Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles.免疫球蛋白在生物分子冠上的沉积决定了临床前和临床纳米颗粒的补体调理效率。
Nat Nanotechnol. 2019 Mar;14(3):260-268. doi: 10.1038/s41565-018-0344-3. Epub 2019 Jan 14.
9
The Potential of Exosomes From Cow Milk for Oral Delivery.牛乳来源外泌体的口服递送潜力。
J Pharm Sci. 2019 Apr;108(4):1496-1505. doi: 10.1016/j.xphs.2018.11.022. Epub 2018 Nov 20.
10
It's All in the Delivery: Designing Hydrogels for Cell and Non-viral Gene Therapies.一切都在传递中：设计水凝胶用于细胞和非病毒基因治疗。
Mol Ther. 2018 Sep 5;26(9):2087-2106. doi: 10.1016/j.ymthe.2018.07.022. Epub 2018 Aug 4.

本文引用的文献

1
Drug delivery systems for prolonged duration local anesthesia.用于长效局部麻醉的药物递送系统。
Mater Today (Kidlington). 2017 Jan-Feb;20(1):22-31. doi: 10.1016/j.mattod.2016.11.019. Epub 2016 Dec 20.
2
Non-specific adsorption of complement proteins affects complement activation pathways of gold nanomaterials.补体蛋白的非特异性吸附会影响金纳米材料的补体激活途径。
Nanotoxicology. 2017 Apr;11(3):382-394. doi: 10.1080/17435390.2017.1306131. Epub 2017 Apr 3.
3
Longitudinal monitoring of skin accumulation of nanocarriers and biologicals with fiber optic near infrared fluorescence spectroscopy (FONIRS).利用光纤近红外荧光光谱法（FONIRS）对纳米载体和生物制剂在皮肤中的蓄积进行纵向监测。
J Control Release. 2017 Feb 10;247:167-174. doi: 10.1016/j.jconrel.2017.01.006. Epub 2017 Jan 6.
4
The drug delivery field needs a well-diversified technology portfolio.药物递送领域需要多样化的技术组合。
J Control Release. 2017 Jan 10;245:177. doi: 10.1016/j.jconrel.2016.12.010.
5
Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer.预先存在的抗聚乙二醇（PEG）抗体与对聚乙二醇化适体培格尼伐汀的严重速发型过敏反应相关。
J Allergy Clin Immunol. 2016 Dec;138(6):1712-1715. doi: 10.1016/j.jaci.2016.04.058. Epub 2016 Jul 14.
6
Subvisible Particle Content, Formulation, and Dose of an Erythropoietin Peptide Mimetic Product Are Associated With Severe Adverse Postmarketing Events.一种促红细胞生成素肽模拟产品的亚可见颗粒含量、制剂和剂量与严重的上市后不良事件相关。
J Pharm Sci. 2016 Mar;105(3):1023-7. doi: 10.1016/S0022-3549(15)00180-X. Epub 2016 Feb 3.
7
Pre-existing anti-polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer.预先存在的抗聚乙二醇抗体与对聚乙二醇化RNA适体培格尼西的首次暴露过敏反应有关。
J Allergy Clin Immunol. 2016 May;137(5):1610-1613.e7. doi: 10.1016/j.jaci.2015.10.034. Epub 2015 Dec 11.
8
An integrated assessment of morphology, size, and complement activation of the PEGylated liposomal doxorubicin products Doxil®, Caelyx®, DOXOrubicin, and SinaDoxosome.聚乙二醇脂质体阿霉素产品多柔比星脂质体注射液（Doxil®）、脂质体多柔比星（Caelyx®）、多柔比星脂质体注射液（DOXOrubicin）和辛糖多柔比星脂质体（SinaDoxosome）的形态、大小和补体激活的综合评估。
J Control Release. 2016 Jan 10;221:1-8. doi: 10.1016/j.jconrel.2015.11.021. Epub 2015 Nov 26.
9
Drug delivery of the future: Chasing the invisible gorilla.未来的药物递送：追逐隐形大猩猩。
J Control Release. 2016 Oct 28;240:2-8. doi: 10.1016/j.jconrel.2015.10.048. Epub 2015 Oct 28.
10
Lessons in simplicity that should shape the future of drug delivery.关于简单性的经验教训，将塑造药物递送的未来。
Nat Biotechnol. 2015 Oct;33(10):1026-7. doi: 10.1038/nbt.3366.