Vitalone Annabella, Di Sotto Antonella, Mammola Caterina Loredana, Heyn Rosemarie, Miglietta Selenia, Mariani Paola, Sciubba Fabio, Passarelli Francesca, Nativio Paola, Mazzanti Gabriela
Department of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Department of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Food Chem Toxicol. 2017 Oct;108(Pt A):63-73. doi: 10.1016/j.fct.2017.07.027. Epub 2017 Jul 13.
Caralluma fimbriata Wall. is currently used as a "natural slimming" food supplement, likely due to its content in pregnane glycosides. In the present study, a commercially available Caralluma fimbriata extract (Slimaluma; CFE, 100 mg/kg) has been evaluated for its ability to affect the ingestive behaviour in female rats, also with reference to the modulation of the brain neuropeptides NPY and ORX.The interference of CFE with α-amylase and lipase enzymes has been investigated in vitro, as possible peripheral mechanism of action. Also, the chemical composition of CFE has been assessed by NMR and spectrophotometric analysis. Results from in vivo study showed that CFE induced effects neither on blood parameters, nor on liver and gut histomorphology. Interestingly, a reduction in body weight gain with an increase in water intake and hypothalamic levels of NPY and ORX peptides were found. Phytochemical analysis, showed CFE contained about 12% of pregnane glycosides and 1.3% of polyphenols. Present results suggest possible effects of C. fimbriata on ingestive behaviour, likely mediated by central and peripheral mechanisms.
肉苁蓉目前被用作一种“天然减肥”食品补充剂，可能是由于其孕烷糖苷的含量。在本研究中，对一种市售的肉苁蓉提取物（Slimaluma；CFE，100mg/kg）影响雌性大鼠摄食行为的能力进行了评估，同时参考了对脑内神经肽NPY和ORX的调节作用。在体外研究了CFE对α-淀粉酶和脂肪酶的干扰，作为可能的外周作用机制。此外，通过核磁共振和分光光度分析评估了CFE的化学成分。体内研究结果表明，CFE对血液参数、肝脏和肠道组织形态均无影响。有趣的是，发现体重增加减少，同时水摄入量以及下丘脑NPY和ORX肽水平增加。植物化学分析表明，CFE含有约12%的孕烷糖苷和1.3%的多酚。目前的结果表明肉苁蓉对摄食行为可能有影响，可能由中枢和外周机制介导。
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