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基础科学研究中良好实验室规范(GLP)的实施:将这一概念的应用拓展至法规合规之外。

Implementation of Good Laboratory Practices (GLP) in basic scientific research: Translating the concept beyond regulatory compliance.

作者信息

Jena G B, Chavan Sapana

机构信息

Facility for Risk Assessment and Intervention Studies, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S. Nagar, Punjab 160062, India.

Facility for Risk Assessment and Intervention Studies, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S. Nagar, Punjab 160062, India.

出版信息

Regul Toxicol Pharmacol. 2017 Oct;89:20-25. doi: 10.1016/j.yrtph.2017.07.010. Epub 2017 Jul 13.

Abstract

The principles of Good Laboratory Practices (GLPs) are mainly intended for the laboratories performing studies for regulatory compliances. However, today GLP can be applied to broad disciplines of science to cater to the needs of the experimental objectives, generation of quality data and assay reproducibility. Considering its significance, it can now be applied in academics; industries as well as government set ups throughout the world. GLP is the best way to promote the reliability, reproducibility of the test data and hence facilitates the international acceptability. Now it is high time to translate and implement the concept of GLP beyond regulatory studies. Thus, it can pave the way for better understanding of scientific problems and help to maintain a good human and environmental health. Through this review, we have made an attempt to explore the uses of GLP principles in different fields of science and its acceptability as well as looking for its future perspectives.

摘要

良好实验室规范(GLPs)原则主要适用于那些为符合法规要求而开展研究的实验室。然而,如今GLP可应用于广泛的科学学科,以满足实验目标、生成高质量数据及测定重现性的需求。鉴于其重要性,它目前可应用于全球范围内的学术界、行业以及政府机构。GLP是提高测试数据可靠性和重现性的最佳方式,从而促进国际认可度。现在是时候将GLP概念翻译并应用于法规研究之外的领域了。因此,它可为更好地理解科学问题铺平道路,并有助于维护良好的人类和环境健康。通过本综述,我们试图探索GLP原则在不同科学领域的用途及其可接受性,并展望其未来前景。

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