Bradshaw Abigail R, Bishop Dorothy V M, Woodhead Zoe V J
Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom.
PeerJ. 2017 Jul 11;5:e3557. doi: 10.7717/peerj.3557. eCollection 2017.
The involvement of the right and left hemispheres in mediating language functions has been measured in a variety of ways over the centuries since the relative dominance of the left hemisphere was first known. Functional magnetic resonance imaging (fMRI) presents a useful non-invasive method of assessing lateralisation that is being increasingly used in clinical practice and research. However, the methods used in the fMRI laterality literature currently are highly variable, making systematic comparisons across studies difficult. Here we consider the different methods of quantifying and classifying laterality that have been used in fMRI studies since 2000, with the aim of determining which give the most robust and reliable measurement. Recommendations are made with a view to informing future research to increase standardisation in fMRI laterality protocols. In particular, the findings reinforce the importance of threshold-independent methods for calculating laterality indices, and the benefits of assessing heterogeneity of language laterality across multiple regions of interest and tasks. This systematic review was registered as a protocol on Open Science Framework: https://osf.io/hyvc4/.
自首次发现左半球相对占主导地位以来的几个世纪里，人们通过多种方式测量了左右半球在介导语言功能中的参与情况。功能磁共振成像（fMRI）是一种有用的非侵入性评估偏侧化的方法，在临床实践和研究中越来越多地被使用。然而，目前fMRI偏侧化文献中使用的方法高度可变，使得跨研究进行系统比较变得困难。在这里，我们考虑了自2000年以来在fMRI研究中用于量化和分类偏侧化的不同方法，目的是确定哪些方法能给出最稳健和可靠的测量结果。我们提出了一些建议，以期为未来的研究提供参考，以提高fMRI偏侧化协议的标准化程度。特别是，这些发现强化了用于计算偏侧化指数的与阈值无关的方法的重要性，以及评估跨多个感兴趣区域和任务的语言偏侧化异质性的好处。本系统评价已在开放科学框架上注册为一项方案：https://osf.io/hyvc4/ 。
